Neuroimmunological links in dermatology: psoriasis as a model disease in stress research

Abstract

Chronic inflammatory skin diseases such as psoriasis vulgaris are widespread and stressful not only for the affected patients but also for our healthcare system. Environmental influences and immune malfunctions are among the most frequently discussed issues. Both are related to modulation of stress-axis function. However, the relevance of the relationship between chronic skin inflammation, neuroimmune regulation and stress remains unclear. Also, the question if an effective anti-inflammatory therapy combined with lifestyle changes can more efficiently open up pathogenic circuits is to be discussed. The aim of this review is therefore to dissect a model disease for chronic inflammation and neuroimmune regulation and to delineate the current knowledge on its psychoneuroimmunologic framework and treatment options within.