The role of miR-139-5p and miR-206 in non-small cell lung cancer (NSCLC) by targeting c-Met

Abstract

Increasing evidences have confirmed that ectopic miRNAs are key regulatory factors in various types of cancers. Both hsa-miRNA-206 (miR-206) and hsa-miRNA-139-5p (miR-139-5p) have been demonstrated that possess anticancer properties in a variety of tissues and organs. In our recent investigations, we discovered miR-139-5p and miR-206 played a crucial role in lung cancer progression. There were extremely low levels of miR-206 and miR-139-5p in NSCLC (non-small cell lung cancer) cell lines as well as expression of them were inhibited in lung cancer tissues, respectively. Moreover, we found that miR-206 through targeting 3′-UTR（3'-untranslated region ）of Bcl-2 and c-Met mRNA that promoted cell apoptosis as well as suppressed non-small cell lung cancer SK-MES-1 and A549 cells colony formation, growth, invasion and metastasis. The analogical phenomenon was also discovered in miR-139-5p that targeted tumorigenic c-Met, which contributed to promotion of apoptosis and inhibition of cell proliferation and migration in non-small cell lung cancer.