Correction of neurodegenerative retinal damage with dimethylaminoethanol derivatives

Abstract

Glaucoma occupies a leading place among the pathologies of the eye, leading to irreversible consequences. Many researchers assign glutamate excitotoxicity a key role in retinal neurodegeneration. This allows us to consider the model of NMDA-induced retinal degeneration as one of the main ones in experimental studies aimed at studying the neuroprotective properties of compounds. We have studied the pharmacological activity of dimethylaminoethanol derivatives in the model of NMDA-induced retinal excitotoxicity. 7 days after the modeling of the pathology, ophthalmoscopic changes in the fundus and the level of microcirculation were assessed. According to the results of the study, it was found that the compound under the laboratory code DMAE 10-19 had the highest activity. The introduction of the compound provided an improvement in the picture of the fundus by 24.4 %, relative to the group with a pathology model, which is a significant difference (p < 0.05). And also there was an increase in the level of microcirculation in the retina, up to 625.4 p.u., which is 37.6 % higher than in the group with the pathology model (p < 0.05). Thus, it was found that the compound under the laboratory code DMAE 10-19 has the highest pharmacological activity, which is characterized by an improvement in the fundus picture and an increase in the level of microcirculation in the retina. Keywords: dimethylaminoethanol derivatives, NMDA, excitotoxicity, retina, rats, the level of microcirculation, ophthalmoscopy