Polycyclic Quinones and Hydroquinones, Antitumor Constituents from Taiwanese Marine Sponge Xestospongia Sp

The Chinese Pharmaceutical Journal Pub Date : 2002-06-01 DOI:10.7019/CPJ.200206.0207

Ya‐Ching Shen, Kuang-Liang Lo, Y. Kuo, R. Chakraborty

引用次数: 2

Abstract

Eight polycyclic quinines and hydroquinones were isolated from marine sponge Xestospongia spp. They are halenaquinone (1), halenaquinol (2), 14-methoxyxestoquinone (3), 15-methoxyxes-toquinone(4), xestoquinone (5), 15-chloro-14-hydroxyxestoquinone (6), adociaquinone A (7) and adociaquinone B (8). Biological screening revealed that compounds 7 and 8 possessed in vitro cytotoxicity against KB 16 and HEP-3B tumor cell lines.

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台湾海绵多环醌类及对苯二酚类抗肿瘤成分

从海绵Xestospongia spp中分离得到8个多环奎宁和对苯二酚类化合物，分别为halenaquinone(1)、halenaquinol(2)、14-甲氧基xestoquinone(3)、15-甲氧基xestoquinone(4)、xestoquinone(5)、15-氯-14-羟基xestoquinone(6)、adociaquinone A(7)和adociaquinone B(8)。生物学筛选结果表明，化合物7和8对KB 16和HEP-3B肿瘤细胞系具有体外细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Chinese Pharmaceutical Journal

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