Changes in the Oral Microbiota Induced by Peri-implantitis: A Meta-Analysis

A. Rodríguez-Archilla, Barbara Palma-Casiano
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Abstract

Background: Peri-implantitis is an infectious disease around dental implants characterized by inflammation of the peri-implant connective tissues and progressive loss of supporting bone, with an estimated prevalence of around 22%. Peri-implantitis microbiota is different from that observed in both periodontitis and healthy implants. Knowledge of this microbiota is crucial for the proper treatment of the disease. Objective: To assess the differences in the oral microbiota in dental implant-bearing patients with and without peri-implantitis. Methods: A search for studies on microbiota and peri-implantitis up to June 2021 was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science, Scopus, ProQuest, LILACS, and Google Scholar. For dichotomous outcomes, the effects of the intervention were expressed as odds ratios (OR) using Mantel-Haenszel (M-H) method with 95% confidence intervals. Results: Twelve studies with 1324 participants were included in this meta-analysis. Peri-implantitis patients were more likely to be carriers of the following microorganisms: Tannerella forsythia (OR=3.17, 95% CI: 1.55 to 6.51, P<0.01); Prevotella intermedia (OR=2.21, 95% CI: 1.73 to 2.82, P<0.001); Treponema denticola (OR=2.18, 95% CI: 1.70 to 2.79, P<0.001); Porphyromonas gingivalis (OR=2.04, 95% CI: 1.16 to 3.59, P=0.01); Fusobacterium nucleatum (OR=1.81, 95% CI: 1.21 to 2.72, P<0.01), and Campylobacter rectus (OR=1.69, 95% CI: 1.32 to 2.17, P<0.001). In contrast, the bacteria Aggregatibacter actinomycetemcomitans and Streptococcus mitis were more prevalent in peri-implantitis patients but not significantly (P>0.05). Conclusion: Peri-implantitis modifies the quantitative and qualitative composition of the oral microbiota.
种植体周围炎引起的口腔微生物群变化:一项荟萃分析
背景:种植体周围炎是一种围绕种植体的感染性疾病,其特征是种植体周围结缔组织的炎症和支撑骨的进行性损失,估计患病率约为22%。种植体周围的微生物群不同于牙周炎和健康种植体。了解这种微生物群对正确治疗这种疾病至关重要。目的:探讨种植体周围炎患者与非种植体炎患者口腔微生物群的差异。方法:在PubMed (MEDLINE, Cochrane Library)、Web of Science、Scopus、ProQuest、LILACS和Google Scholar等数据库中检索截至2021年6月有关微生物群和种植体周围炎的研究。对于二分类结果,使用Mantel-Haenszel (M-H)方法以95%置信区间的优势比(OR)表示干预的效果。结果:本荟萃分析纳入了12项研究,共1324名受试者。种植体周围炎患者更容易携带以下微生物:单宁菌连体(OR=3.17, 95% CI: 1.55 ~ 6.51, P0.05)。结论:种植体周围炎改变了口腔微生物群的定量和定性组成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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