Efficacy of Graphene Nanosheets on the Plasma Sprayed Hydroxyapatite Coating: Improved Strength, Toughness and In-Vitro Bioperformance With Osteoblast

Biomaterials eJournal Pub Date : 2021-02-14 DOI:10.2139/ssrn.3805229

Yao Chen, Jia Ren, Yufeng Sun, Weiwei Liu, Xiaolong Lu, S. Guan

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引用次数: 9

Abstract

Abstract Graphene nanosheet (GNS) reinforced HA coating on Ti6Al4V substrate, fabricated using plasma spray, was developed for biomedical applications. Microstructural observation corroborated that the adding GNSs homogeneously distributed in the GNS/HA coating with typical lamellar structure featured by GNSs acting as binder between the discrete HA splats. Meanwhile, GNSs were observed to get in direct contact with HA matrix and form a clean GNS-HA interface without interfacial product. Results of various indentation tests showed simultaneous improvement in both indentation yield strength (~379 MPa) and fracture toughness (0.78 ± 0.17 MPam1/2), mainly attributing to synergetic toughening and strengthening mechanisms associated with the adding GNSs such as load transfer, GNS pull-out, inter-layer sliding of a GNS, crack branching, GNS bridging and crack deflection. In addition, the GNS/HA coating exhibited improved biocompatible with MG-63 cell in terms of its attachment, adhesion strength, proliferation and differentiation. Hence, the GNS/HA composite coating with improved strength, toughness and enhanced biocompatibility makes it a promising candidate for bone regeneration and implantation.

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石墨烯纳米片在等离子喷涂羟基磷灰石涂层上的效果:提高成骨细胞的强度、韧性和体外生物性能

采用等离子喷涂技术在Ti6Al4V基体上制备了石墨烯纳米片增强羟基磷灰石涂层，并将其应用于生物医学领域。显微组织观察证实，添加的GNSs均匀分布在GNS/HA涂层中，具有典型的片层结构，GNSs在分散的HA薄片之间起到粘结剂作用。同时，观察到GNSs与HA矩阵直接接触，形成干净的GNS-HA界面，无界面产物。压痕屈服强度(~379 MPa)和断裂韧性(0.78 ± 0.17 MPam1/2)同时提高，这主要是由于添加GNS的载荷传递、GNS拉出、GNS层间滑动、裂纹分支、GNS桥接和裂纹偏转等协同增韧强化机制所致。此外，GNS/HA涂层与MG-63细胞在附着、粘附强度、增殖和分化等方面均表现出较好的生物相容性。因此，GNS/HA复合涂层具有较好的强度、韧性和生物相容性，是骨再生和骨植入的理想材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomaterials eJournal

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