Magnetic Resonance Imaging Characteristics of Brain Structure and Neuroendocrine Changes in Patients with First-Episode Schizophrenia

IF 0.4 4区化学 Q4 CHEMISTRY, PHYSICAL

Concepts in Magnetic Resonance Part A Pub Date : 2023-04-03 DOI:10.1155/2023/8953242

Kai Yang, Xianxiang Zeng, Li Hu, Jinhong Chen, Weiwei Zhu, Yu Wang, Xiaoxiong Zhao

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引用次数: 1

Abstract

This research was aimed to investigate the magnetic resonance imaging (MRI) features of brain structure and neuroendocrine levels in patients with first-episode schizophrenia. 25 hospitalized patients with first-episode schizophrenia were selected as the observation group, while 25 healthy people were selected as the control group. All the objects underwent MRI examination, and the images as well as gray matter density of the original image data were analyzed under voxel-based morphometry (VBM). The cortisol and prolactin in the observation group were detected, and the levels were compared. The Pearson correlation analysis was adopted to analyze the correlation between cortisol and prolactin levels and the total score of the Positive and Negative Syndrome Scale (PANSS). The results showed that the gray matter volume of the precentral gyrus, superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, postcentral gyrus, inferior parietal lobule, superior parietal lobule, and anterior cingulate cortex of the observation group decreased, while the volume of cerebellar gray matter increased. The levels of cortisol and prolactin in the observation group (387.54 ± 117.69 μg/L and 804.16 ± 267.13 μIU/mL, respectively) were significantly higher than those in the control group (138.46 ± 62.47 μg/L and 397.54 ± 203.82 μIU/mL, respectively), and the differences were statistically significant ( P < 0.05 ). The results of the Pearson correlation test showed that the higher the cortisol level, the more severe the schizophrenia (r = 0.421 and P = 0.013 ), while the prolactin level was not directly related to the severity of schizophrenia (r = 0.019 and P = 0.568 ). In conclusion, the MRI features based on the VBM technology can accurately assess the changes of gray matter; the levels of cortisol and prolactin in patients with first-episode schizophrenia were significantly higher than those in healthy people; and the higher the cortisol level, the more severe the schizophrenia symptoms. This study provided a certain research basis for MRI features of brain structure and neuroendocrine changes in patients with first-episode schizophrenia.

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首发精神分裂症患者脑结构和神经内分泌变化的磁共振成像特征

本研究旨在探讨首发精神分裂症患者脑结构和神经内分泌水平的磁共振成像(MRI)特征。选取住院首发精神分裂症患者25例作为观察组，选取健康人群25例作为对照组。所有对象均行MRI检查，在基于体素的形态测量(voxel-based morphometry, VBM)下对图像及原始图像数据的灰质密度进行分析。观察组患者检测皮质醇、催乳素水平，并进行比较。采用Pearson相关分析分析皮质醇、催乳素水平与PANSS (Positive and Negative Syndrome Scale)总分的相关性。结果显示，观察组大鼠中央前回、额上回、额中回、额下回、中央后回、顶叶下小叶、顶叶上小叶、前扣带皮层灰质体积减小，小脑灰质体积增大。观察组患者皮质醇、催乳素水平(分别为387.54±117.69 μIU/ L、804.16±267.13 μIU/mL)显著高于对照组(分别为138.46±62.47 μIU/ L、397.54±203.82 μIU/mL)，差异均有统计学意义(P < 0.05)。Pearson相关检验结果显示，皮质醇水平越高，精神分裂症越严重(r = 0.421, P = 0.013)，而催乳素水平与精神分裂症的严重程度无直接关系(r = 0.019, P = 0.568)。综上所述，基于VBM技术的MRI特征可以准确评估灰质的变化;首发精神分裂症患者皮质醇和催乳素水平显著高于健康人群;皮质醇水平越高，精神分裂症症状越严重。本研究为首发精神分裂症患者脑结构及神经内分泌变化的MRI特征提供了一定的研究依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Concepts in Magnetic Resonance Part A 物理-光谱学

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Concepts in Magnetic Resonance Part A brings together clinicians, chemists, and physicists involved in the application of magnetic resonance techniques. The journal welcomes contributions predominantly from the fields of magnetic resonance imaging (MRI), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR), but also encourages submissions relating to less common magnetic resonance imaging and analytical methods. Contributors come from academic, governmental, and clinical communities, to disseminate the latest important experimental results from medical, non-medical, and analytical magnetic resonance methods, as well as related computational and theoretical advances. Subject areas include (but are by no means limited to): -Fundamental advances in the understanding of magnetic resonance -Experimental results from magnetic resonance imaging (including MRI and its specialized applications) -Experimental results from magnetic resonance spectroscopy (including NMR, EPR, and their specialized applications) -Computational and theoretical support and prediction for experimental results -Focused reviews providing commentary and discussion on recent results and developments in topical areas of investigation -Reviews of magnetic resonance approaches with a tutorial or educational approach