The Preparation and the Release Properties of Nanometer Titanium Dioxide

Abstract

Nano titanium dioxide (TiO2) was synthesized by using butyl titanium as raw material with sol-gel method and assisted with ultrasound. The products were characterized by X-Ray diffraction (XRD), Fourier transform infrared spectrophotometry (FTIR). The effects of hydrothermal temperature, ultrasonic time, ultrasonic power and acetic acid dosage were all investigated, and the optimal conditions for the crystal of nano TiO2 were acid dosage 8 mL, temperature at 40°C, extration time 50 min and the ultrasonic power 240 W. A series of drug release experiments were employed in vitro, we found that the maximum drug loading rate reached 67.30%. The results reveal that nano TiO2 is a promising biomedical nanomaterial in the application of drug loading system.