UDP-glucose 6-dehydrogenase expression as a predictor of survival in patients with pulmonary adenocarcinoma

IF 0.3 Q4 ONCOLOGY
S. Saha, Sha Yao, O. Elakad, Anna-Maria Lois, H. Henric-Petri, J. Buentzel, M. Hinterthaner, B. Danner, P. Ströbel, A. Emmert, H. Bohnenberger
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引用次数: 3

Abstract

Supplemental Digital Content is available in the text. Background: UDP-glucose-6-dehydrogenase (UGDH) plays an important role in the production of hyaluronic acid, an extracellular matrix component that is responsible for the promotion of normal cellular growth and migration. Increased levels of UGDH have been linked to the progression of epithelial cancers, such as those of the breast, colon and prostate. Therefore we aimed to analyze if the expression level of UGDH does also influence patients survival of lung cancer patients. Methods: UGDH expression levels were analyzed by immunohistochemistry in 96 samples of pulmonary adenocarcinoma (AC), 84 cases of squamous cell lung carcinoma (SQCLC) and 33 samples of small cell lung cancer (SCLC) and correlated with clinicopathologic characteristics and patient outcome. Results: UGDH was expressed in 62.5% cases of AC, 70.2% cases of SQCLC, and 48.5% cases of SCLC. In AC, expression of UGDH was significantly associated with lymph node metastasis and worse overall survival of the affected patients. However, UGDH expression had no significant correlation to prognosis in SQCLC or SCLC patients. Conclusions: In our study, expression of UGDH was associated with worse prognosis of patients with pulmonary adenocarcinoma so that expression of UGDH might help to guide treatment decisions. Furthermore, UGDH might present a potential novel drug target in AC as it displays inhibitable catalytic activity.
udp -葡萄糖6-脱氢酶表达作为肺腺癌患者生存的预测因子
补充数字内容可在文本中找到。背景:udp -葡萄糖-6-脱氢酶(UGDH)在透明质酸的产生中起重要作用,透明质酸是一种细胞外基质成分,负责促进正常的细胞生长和迁移。UGDH水平的升高与上皮性癌症的进展有关,如乳腺癌、结肠癌和前列腺癌。因此,我们旨在分析UGDH的表达水平是否也影响肺癌患者的生存。方法:应用免疫组化方法分析96例肺腺癌(AC)、84例鳞状细胞肺癌(SQCLC)和33例小细胞肺癌(SCLC)中UGDH的表达水平,并与临床病理特征和患者转归进行相关性分析。结果:UGDH在AC、SQCLC和SCLC中分别表达62.5%、70.2%和48.5%。在AC中,UGDH的表达与淋巴结转移和受影响患者的总生存率显著相关。然而,在SQCLC和SCLC患者中,UGDH的表达与预后无显著相关性。结论:在我们的研究中,UGDH的表达与肺腺癌患者预后不良相关,UGDH的表达可能有助于指导治疗决策。此外,由于UGDH具有抑制性的催化活性,因此可能成为AC中潜在的新型药物靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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