Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats

Neuroscience Research Communications Pub Date : 2004-09-01 DOI:10.1002/NRC.20026

Eun-Kyung Kim, Hong Kim, Myoung-Hwa Lee, Y. S. Kim, Hye-Young Yang, Hyun-kyung Chang, Taeck-Hyun Lee, M. Jang, M. Shin, S. Lee, Hee-Hyuk Lee, Mal-Soon Shin, Chang-Ju Kim

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引用次数: 5

Abstract

During the prenatal period, development of individual is influenced by the environmental factors. In mammals, 5-hydroxytryptamine (5-HT) is a central neurotransmitter that regulates behavioral functions in the vertebrate brain. Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the 5-HT synthesis. Various stresses are known to modulate the 5-HT synthesis and the TPH expression. In the present study, the influence of prenatal noise and music aplication on the 5-HT synthesis and the TPH expression in the dorsal and median raphe of young rats was investigated. Prenatal noise application increased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. Prenatal music application, in contrast, decreased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. The present study suggests that prenatal stimuli including noise and music may affect the emotional state of offspring.

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产前噪声和音乐对幼鼠中缝核5-羟色胺合成和色氨酸羟化酶表达的影响

在产前阶段，个体的发育受到环境因素的影响。在哺乳动物中，5-羟色胺(5-HT)是调节脊椎动物大脑行为功能的中枢神经递质。色氨酸羟化酶(TPH)是5-羟色胺合成中的一种限速酶。已知各种应激可调节5-HT合成和TPH表达。本研究探讨了产前噪声和音乐对幼鼠中背和中叶5-羟色胺合成及TPH表达的影响。产前施加噪声可增加子代中缝背核和中缝中核5-HT合成和TPH表达。相比之下，产前音乐处理降低了子代中缝背核和正中核中5-HT的合成和TPH的表达。目前的研究表明，包括噪音和音乐在内的产前刺激可能会影响后代的情绪状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neuroscience Research Communications

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