COMPARATIVE INFLUENCE OF TRENTHAL AND XANTHINOL NICOTINATE ON THE FUNCTIONAL STATE OF KIDNEYS IN RATS UNDER CONDITIONS OF SALT LOADING

Abstract

The aim – to investigate the comparative influence of trenthal and xanthinol nicotinateon the functional state of the rat kidneys under conditions of salt loading after a singleand durable (7 days) administration of preparations.Material and methods. Changes of excretory, water- and ion-regulating functions of thekidneys following a single and long trenthal and xanthinol nicotinate administration atdoses of 3mg/kg under conditions of salt loading with NaCl solution 0,45% were studiedin the experiments on non-linear white rats.Results. Both the rapid response of the kidneys after a single injection of trenthaland xanthinol nicotinate and more significant changes of the renal function followingrepeated (7 days) drugs’ administration under conditions of salt hydration with NaCl0.45% solution were observed. Comparative estimation of the renal action at a singleadministration has shown that xanthinol nicotinate activates water-, ion-regulating andexcretory function of kidneys more significantly than trenthal. After xanthinol nicotinateadministration the urine output in rats increased 74%, natriuresis - 66%, creatinineexcretion – 52% in comparison with the control, while following trenthal administrationthe indices under study increased only 62%, 33% and 34% correspondingly.Under conditions of salt loading water-regulating function of kidneys activated moresignificantly following durable (7 days) administration than after a single introduction ofpreparations. Under trenthal influence diuresis increased 1.8 times, xanthinol nicotinate– 1.9 times in comparison with the control. Trenthal increased endogenous creatinineexcretion – 1.4 times and xanthinol nicotinate – 1.6 times.Natriuresis increased almost 2 times, trenthal - 1.4 times under xanthinol nicotinateinfluence. The natriuretic effect of xanthinol nicotinate is 55% higher than that oftrenthal. Positive correlative relation has been established between increased urinationand natriuresis only after durable xanthinol nicotinate administration (r=0,784, p<0,05).Trenthal appeared to be more pronounced kaliurretic.Conclusions. Excretory, water- and ion-regulating renal function is activated following asingle and protracted (7 days) introduction of methylxanthine derivatives – trenthal andxanthinol nicotinate at a dose of 3mg/kg under hydration conditions with NaCl solution0,45%. Renal effects of the preparations under study is characterized by an increaseof endogenous creatinine excretion. With long-term administration of the preparationsnatriuretic effect predominates in xanthinol nicotinate, kaliuretic effect - in trenthal.