Factors of QTc interval prolongation in patients with arterial hypertension

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
N. Y. Tselik, O. Bilchenko
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引用次数: 0

Abstract

The relevance of determining the factors of the prolonged QTc interval development in patients with arterial hypertension is high, as it solves the issue of preliminary diagnosis among patients from risk groups and allows adjusting the diagnostic and therapeutic tactics of managing such patients. Aim: to determine factors for the development of prolonged average daily QTc interval in patients with arterial hypertension. Materials and methods. The study included 195 patients with arterial hypertension, who were divided into 2 subgroups: 175 individuals with a normal average daily duration of the QTc interval and 20 patients with a prolonged average daily duration of the QTc interval. All the patients underwent 24-hour heart rate monitoring and determination of blood pressure variability. At the stage of involving patients in the study, the following were performed: anamnesis collection and determination of physical data (estimation of systolic and diastolic blood pressure). Results. The study has revealed risk factors of daily QTc interval prolongation in hypertensive patients with further developing a prognostic model with high sensitivity (88.9 %) and specificity (70.6 %). Prolongation of QTc in patients with hypertension was associated with such parameters: male sex (OR = 4.292 [95.0 % CI 1.337–13.779], Р = 0.014), body mass index (OR = 1.107 [95.0 % CI 0.987–1.243], Р = 0.083), mean 24-hour diastolic (OR = 1.076 [95.0 % CI 1.017–1.139], Р = 0.011) and pulse blood pressure (OR = 1.075 [95.0 % CІ 1.012–1.141], Р = 0.018), time since hypertension was diagnosed (OR = 1.093 [95.0 % CI 0.997–1.197], Р = 0.057) and office pulse blood pressure (OR = 0.948 [95.0 % CІ 0.900–0.999], Р = 0.046). Conclusions. The study has determined risk factors of developing a prolonged average daily QTc interval in patients with hypertension, which will allow correcting diagnostic and treatment tactics of management for patients from risk groups.
高血压病患者QTc间期延长的影响因素
确定动脉性高血压患者QTc间期延长发展的相关因素,解决了高危人群患者的初步诊断问题,调整了该类患者的诊治策略,具有较高的相关性。目的:探讨高血压患者平均每日QTc间期延长的影响因素。材料和方法。该研究纳入195例动脉高血压患者,将其分为2个亚组:175例QTc间期平均日持续时间正常的患者和20例QTc间期平均日持续时间延长的患者。所有患者均接受24小时心率监测和血压变异性测定。在患者参与研究的阶段,进行了以下工作:收集记忆和确定物理数据(估计收缩压和舒张压)。本研究揭示了高血压患者每日QTc间期延长的危险因素,并进一步建立了敏感性(88.9%)和特异性(70.6%)较高的预后模型。高血压患者QTc的延长与以下参数相关:男性(或= 4.292 (95.0% CI 1.337 - -13.779),Р= 0.014),身体质量指数(或= 1.107 (95.0% CI 0.987 - -1.243),Р= 0.083),意思是24小时舒张压(或= 1.076 (95.0% CI 1.017 - -1.139),Р= 0.011)和脉搏血压(或= 1.075 (95.0% CІ1.012 - -1.141),Р= 0.018),以来被诊断为高血压(或= 1.093 (95.0% CI 0.997 - -1.197),Р= 0.057)和办公室血压脉搏(或= 0.948 (95.0% CІ0.900 - -0.999),Р= 0.046).Conclusions。本研究确定了高血压患者平均每日QTc间隔延长的危险因素,为高危人群患者的诊断和治疗策略的调整提供了依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Zaporozhye Medical Journal
Zaporozhye Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
72
审稿时长
8 weeks
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