The expression and clinical significance of fractional exhaled nitric oxide and indoleamine 2, 3 dioxygenase in children with allergic asthma

Central Plains Medical Journal Pub Date : 2020-02-10 DOI:10.3760/CMA.J.ISSN.1674-4756.2020.03.019

Chunlin Zhang, Jiangtao Niu, Jinlin Zhang

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Abstract

Objective To investigate the expression of fractional exhaled nitric oxide (FeNO) and indoleamine 2, 3 dioxygenase (IDO) in children with allergic asthma and their diagnostic values for the disease. Methods Sixty children with allergic asthma hospitalized and treated in Luoyang Maternal and Child Health Hospital from 2016 to 2019 were selected as observation group, and 60 healthy children who underwent physical examination during the same time period in the hospital were selected as control group. The levels of FeNO, IDO, eosinophils and lung function of the two groups were observed, and the correlation among them was also analyzed. Then the diagnostic values of FeNO and IDO levels for allergic asthma were analyzed by receiver operating characteristics (ROC) curve. Results The observation group has higher FeNO level and lower IDO activity than the control group (P<0.05). The forced expiratory volume in 1 second (FEV1)/ forced vital capicity (FVC) levels in the observation group were significantly lower than those in the control group (P<0.05), and the eosinophil count was significantly higher than that in the control group (P<0.05). FeNO levels were negatively correlated with FEV1/FVC in children with allergic asthma (r=-0.667, P<0.05), and positively correlated with eosinophil count (r=0.813, P<0.05). The level of IDO was positively correlated with FEV1/FVC (r=0.725, P<0.05), and negatively correlated with eosinophil count (r=-0.583, P<0.05). ROC curve analysis showed that single FeNO, single IDO and FeNO combined with IDO had certain diagnostic value for allergic asthma in children. However, FeNO combined with IDO has the highest diagnostic value for allergic asthma in children, with area under curve, sensitivity and specificity as 0.937, 83.3%, and 100%, respectively. Conclusions Children with allergic asthma have increased FeNO level and decreased IDO activity, and the combined detection of FeNO and IDO has high diagnostic value for allergic asthma in children. Key words: Fractional exhaled nitric oxide; Indoleamine 2, 3 Dioxygenase; Allergic asthma; Expression level; Diagnostic value

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儿童变应性哮喘分式呼出一氧化氮和吲哚胺2,3双加氧酶的表达及临床意义

目的探讨分式呼气型一氧化氮(FeNO)和吲哚胺2,3双加氧酶(IDO)在儿童变应性哮喘中的表达及其诊断价值。方法选择2016 - 2019年在洛阳市妇幼保健院住院治疗的过敏性哮喘患儿60例作为观察组，同期在该院体检的健康儿童60例作为对照组。观察两组患者血清FeNO、IDO、嗜酸性粒细胞及肺功能水平，并分析其相关性。采用受试者工作特征(ROC)曲线分析FeNO、IDO水平对变应性哮喘的诊断价值。结果观察组患者FeNO水平高于对照组，IDO活性低于对照组(P<0.05)。观察组患者1秒用力呼气量(FEV1)/用力肺活量(FVC)水平显著低于对照组(P<0.05)，粒细胞计数显著高于对照组(P<0.05)。过敏性哮喘患儿FeNO水平与FEV1/FVC呈负相关(r=-0.667, P<0.05)，与嗜酸性粒细胞计数呈正相关(r=0.813, P<0.05)。IDO水平与FEV1/FVC呈正相关(r=0.725, P<0.05)，与嗜酸性粒细胞计数负相关(r=-0.583, P<0.05)。ROC曲线分析显示，单次FeNO、单次IDO及FeNO联合IDO对儿童变应性哮喘有一定的诊断价值。而FeNO联合IDO对儿童变应性哮喘的诊断价值最高，曲线下面积为0.937，敏感性为83.3%，特异性为100%。结论变应性哮喘患儿FeNO水平升高，IDO活性降低，联合检测FeNO和IDO对儿童变应性哮喘具有较高的诊断价值。关键词:分式呼出一氧化氮;吲哚胺2,3双加氧酶;过敏性哮喘;表达水平;诊断价值

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Central Plains Medical Journal

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