Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products

International Journal of Drug Delivery Pub Date : 2010-12-03 DOI:10.5138/IJDD.2010.0975.0215.02039

O. Mashinchian, R. Salehi, G. Dehghan, Ayoub Aganejad, S. Davaran, Y. Omidi

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引用次数: 16

Abstract

The purpose of this research was to synthesize polymer based smart nanosystems for delivery of important bioactive natural products such as sesquiterpene coumarin derivatives of ferula szowitsiana, farnesiferol C as a potent anticancer. To this aim, polymeric micelles were prepared using Nisopropylacrylamide (NIPAAM), vinyl pyrrolidone (VP) and methacrylate (MAA) as monomers which were cross-linked with N, N-methylene bisacrylamide (MBA). The molar ratio of the PNIPAAm: VP: MAA group was 75.7:9.5:14.8. These micelles were further characterized upon their physicochemical properties using particle size analyzer, FT-IR, H-/C-NMR, HPLC. Particle size analyzer resulted in ~500 nm micelles with ~95% drug entrapments. Drug release from the polymeric micelles after 300 hours at 37°C and 40°C were 60 and 98 %, respectively. Upon these findings, it is proposed that the P (N-isopropylacrylamide-co-Methacrylic acid-coVinylpyrrolidone) micelles may be considered as thermosensitive delivery nanosystem.

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新型热敏聚(n -异丙基丙烯酰胺-共乙烯基吡咯烷酮-共甲基丙烯酸)纳米体系用于天然产物的递送

本研究的目的是合成基于聚合物的智能纳米系统，用于递送重要的生物活性天然产物，如阿魏的倍半萜香豆素衍生物，作为一种有效的抗癌药物。为此，以异丙基丙烯酰胺(NIPAAM)、乙烯基吡啶酮(VP)和甲基丙烯酸酯(MAA)为单体，与N, N-亚甲基双丙烯酰胺(MBA)交联制备了聚合物胶束。PNIPAAm: VP: MAA的摩尔比为75.7:9.5:14.8。采用粒度分析仪、FT-IR、H-/C-NMR、HPLC等对胶束进行了理化性质表征。粒径分析仪测定的胶束为~500 nm，药物包封率为~95%。37℃和40℃作用300小时后，聚合物胶束的药物释放率分别为60%和98%。在此基础上，提出了P (n -异丙基丙烯酰胺-共甲基丙烯酸-聚乙烯基吡咯烷酮)胶束可以被认为是热敏递送纳米体系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Drug Delivery

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