A Cross-Sectional Study of Sialic Acids Level in Breast Cancer Patients Attending Ahmadu Bello University Teaching Hospital Zaria, North-Western Nigeria: Preliminary investigations and Implications on Disease Subtypes, Grade and Chemotherapy Courses

S. Ibrahim, A. Muhammad, S. Mada, Abur P. Pase, Saad A Ahmed, S. Ibrahim, Abubakar A. Maru, G. E. Forcados, Ndidi S. Uche, M. Abubakar
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Abstract

Abstract Due to the challenges associated with breast cancer prognosis, this study examined sialic acid levels based on subtypes, grades and therapeutic courses among breast cancer patients presenting at Ahmadu Bello University Teaching Hospital (ABUTH) in North-Western Nigeria between June 2019 and December 2020. This was a cross-sectional study. Sociodemographic characteristics, total sialic acid (TSA), free sialic acid (FSA), bound sialic acid (BSA) and haematological parameters were determined. The mean age of the respondents was 47.46 ± 10.71 years, and the modal age range was 41-50 years. About 40% of the patients had triple-negative breast cancer subtype, and 83.1% had invasive carcinoma. There was an association between breast cancer grade and body mass index (χ2= 26.306, P= 0.001). The TSA, FSA and BSA concentrations were significantly (P<0.05) higher in luminal A and triple-negative breast cancer patients when compared to apparently healthy controls and were highest in stage IV patients. The TSA correlated with the third and sixth chemotherapy courses. Significant (P<0.05) decrease was observed in PCV and Hb among the breast cancer patients irrespective of subtype compared to healthy control. The results suggest that TSA, FSA and BSA were higher in breast cancer patients, necessitating further research on their possible prognostic implications.
尼日利亚西北部扎里亚Ahmadu Bello大学教学医院乳腺癌患者唾液酸水平的横断面研究:对疾病亚型、分级和化疗疗程的初步调查和影响
由于与乳腺癌预后相关的挑战,本研究在2019年6月至2020年12月期间,在尼日利亚西北部的Ahmadu Bello大学教学医院(ABUTH)就诊的乳腺癌患者中,根据亚型、分级和治疗过程检测了唾液酸水平。这是一项横断面研究。测定社会人口学特征、总唾液酸(TSA)、游离唾液酸(FSA)、结合唾液酸(BSA)和血液学参数。调查对象平均年龄为47.46±10.71岁,年龄分布在41 ~ 50岁之间。约40%的患者为三阴性乳腺癌亚型,83.1%的患者为浸润性癌。乳腺癌分级与体重指数存在相关性(χ2= 26.306, P= 0.001)。与表面健康的对照组相比,luminal A和三阴性乳腺癌患者的TSA、FSA和BSA浓度显著(P<0.05)升高,且在IV期患者中最高。TSA与第三次和第六次化疗相关。与健康对照组相比,不同亚型乳腺癌患者的PCV和Hb均显著降低(P<0.05)。结果提示乳腺癌患者中TSA、FSA和BSA较高,需要进一步研究其可能的预后意义。
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