Gene Activation by the Cytokine-Driven Transcription Factor STAT1

R. Nast, Julia Staab, T. Meyer
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引用次数: 4

Abstract

Signal transducers and activators of transcription (STATs) are a family of cytokine-regulated transcription factors, which serve the dual role of external signal transduction and transcriptional activation. The founding member of this family, STAT1, is involved in a plethora of cellular processes, including interferon-dependent upregulation of various effector mechanisms in immune and non-immune cells to control bacterial, fungal and parasitic infections. In this chapter, we discuss the principles of STAT1-driven gene expression and focus on the clinical phenotypes of various human STAT1 mutations. In particular, we highlight the significance of sequence-specific DNA binding and intact nucleocytoplasmic shuttling for full transcriptional activation of interferon-driven target genes.
细胞因子驱动转录因子STAT1的基因激活
信号转导和转录激活因子(Signal transducers and activators of transcription, STATs)是一类细胞因子调控的转录因子,具有外部信号转导和转录激活的双重作用。这个家族的创始成员STAT1参与了大量的细胞过程,包括免疫和非免疫细胞中各种效应机制的干扰素依赖性上调,以控制细菌、真菌和寄生虫感染。在本章中,我们讨论了STAT1驱动基因表达的原理,并重点讨论了各种人类STAT1突变的临床表型。特别是,我们强调序列特异性DNA结合和完整的核细胞质穿梭对于干扰素驱动靶基因的完全转录激活的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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