Polyphenols as Tyrosine Kinase Inhibitors for the Treatment of Metastatic Cancers: Current and Future Perspective

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
S. Hussain, Q. Alhadidi
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引用次数: 0

Abstract

Cancer is the world's biggest cause of death as a whole. The higher cancer mortality rate is related to metastasis, which is a major stumbling block in cancer treatment. Polyphenols are a diverse set of antioxidant-rich natural compounds that are often used in cancer treatments as chemopreventives and adjuvants. To find publications that highlight the topic of this review paper, a thorough literature search was conducted in several electronic databases such as PubMed Central, Google Scholar, Scopus, and Medline. Many signaling pathways are involved in the metastatic cascade, including the tyrosine kinase pathway. Tyrosine kinases are a group of enzymes involved in the control of cancer spread. Polyphenols' true role in cancer metastasis remains unappreciated, despite a large body of research proving their antimetastatic effects. As a result, the current work lays out cancer metastasis signaling pathways, stressing the importance of tyrosine kinases in the metastatic process. Polyphenols can suppress tyrosine kinase activity, which contributes to their antimetastatic characteristics. The importance of polyphenols in preventing cancer metastasis by interfering with the tyrosine kinase signaling cascade is highlighted in this work, which could lead to the development of future antimetastatic drugs.
多酚作为酪氨酸激酶抑制剂治疗转移性癌症:当前和未来的观点
癌症是世界上最大的死亡原因。癌症的高死亡率与转移有关,这是癌症治疗的主要障碍。多酚是一种富含抗氧化剂的天然化合物,常作为化学预防剂和佐剂用于癌症治疗。为了找到突出这篇综述论文主题的出版物,我们在PubMed Central、b谷歌Scholar、Scopus和Medline等几个电子数据库中进行了全面的文献检索。许多信号通路参与转移级联,包括酪氨酸激酶途径。酪氨酸激酶是一组参与控制癌症扩散的酶。尽管大量研究证明了多酚的抗转移作用,但它在癌症转移中的真正作用仍未得到充分认识。因此,目前的研究阐明了癌症转移的信号通路,强调了酪氨酸激酶在转移过程中的重要性。多酚可以抑制酪氨酸激酶活性,这有助于它们的抗转移特性。本研究强调了多酚通过干扰酪氨酸激酶信号级联在预防癌症转移中的重要性,这可能会导致未来抗转移药物的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
INDONESIAN JOURNAL OF PHARMACY
INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-
CiteScore
1.20
自引率
0.00%
发文量
38
审稿时长
12 weeks
期刊介绍: The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.
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