Simultaneous Determination of nicotinamide, kojic acid, Tranexamic acid, raspberry glycoside, azelaic acid, magnesium ascorbate phosphate and β-Arbutin in whitening cosmetics by UPLC-MS/MS

MATEC Web of Conferences Pub Date : 2023-01-01 DOI:10.1051/matecconf/202338001005

Xiao Zou, Lixiu Yan, Xiaofang Luo, Enting Wang, Mingjuan Zhang, Wuping Huang, Wulin Li, L. Tong

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Abstract

A UPLC-MS/MS method was developed for simultaneous determination of 7 whitening ingredients: nicotinamide, kojic acid, Tranexamic acid, raspberry glycoside, azelaic acid, magnesium ascorbate phosphate and β-Arbutin in cosmetics. The whitening active components were extracted from cosmetics by supersonic extraction with sodium chloride and dichloromethane to disperse the sample, and supersonic extraction with 0.015 mol/L potassium dihydrogen phosphate solution purified by HLB solid phase extraction column, scanned and detected by electrospray ionization source with positive and negative ion alternate scanning mode and multiple reaction monitoring mode. The results showed that the whitening active ingredients were separated within 3 minutes, with a good linear relationship (R>0.999), and the detection limit was 0.10mg/kg~0.75mg/kg. The recoveries (n=6) were 78.84%-104.85%, and the RSDs were 0.24%-11.35%. This method is suitable for the rapid determination of whitening active ingredients in cosmetics.

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UPLC-MS/MS同时测定美白化妆品中烟酰胺、曲酸、氨甲环酸、覆盆子苷、壬二酸、磷酸抗坏血酸镁和β-熊果苷的含量

建立了同时测定化妆品中烟酰胺、曲酸、氨甲环酸、覆盆子苷、壬二酸、磷酸抗坏血酸镁和β-熊果苷7种美白成分的UPLC-MS/MS方法。采用氯化钠和二氯甲烷超声提取分散样品，采用HLB固相萃取柱纯化0.015 mol/L磷酸二氢钾溶液超声提取，采用正负离子交替扫描模式和多反应监测模式电喷雾电离源扫描检测。结果表明，美白活性成分在3 min内分离得到，线性关系良好(R为0 0.999)，检出限为0.10mg/kg~0.75mg/kg。加样回收率为78.84% ~ 104.85% (n=6)， rsd为0.24% ~ 11.35%。本方法适用于化妆品中美白活性成分的快速测定。

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来源期刊

MATEC Web of Conferences

自引率

0.00%

发文量

342

审稿时长

6 weeks

期刊介绍： MATEC Web of Conferences is an Open Access publication series dedicated to archiving conference proceedings dealing with all fundamental and applied research aspects related to Materials science, Engineering and Chemistry. All engineering disciplines are covered by the aims and scope of the journal: civil, naval, mechanical, chemical, and electrical engineering as well as nanotechnology and metrology. The journal concerns also all materials in regard to their physical-chemical characterization, implementation, resistance in their environment… Other subdisciples of chemistry, such as analytical chemistry, petrochemistry, organic chemistry…, and even pharmacology, are also welcome. MATEC Web of Conferences offers a wide range of services from the organization of the submission of conference proceedings to the worldwide dissemination of the conference papers. It provides an efficient archiving solution, ensuring maximum exposure and wide indexing of scientific conference proceedings. Proceedings are published under the scientific responsibility of the conference editors.