Study on the relationship between growth arrest-specific protein 6 and acute myocardial infarction

Q4 Health Professions

中华检验医学杂志 Pub Date : 2020-03-11 DOI:10.3760/CMA.J.ISSN.1009-9158.2020.03.020

Di Li, Y. Lyu, Huan Liu, Yan Li

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Abstract

Objective To explore the relationship between growth arrest-specific protein 6 (Gas6) and acute myocardial infarction (AMI). Methods Patients were included from Renmin Hospital of Wuhan University between January to June 2018. A total of 103 patients with angina pectoris aged 60.20±9.35 were included as angina pectoris group. A total of 102 patients with myocardial infarction aged 58.85±9.80 were included as AMI group. A total of 130 healthy individuals aged 63.14±10.40 were included as healthy control. Spearman analysis was performed to investigate the correlations between Gas6 and risk factors of (coronary heart disease, CHD). Logistic regression was performed to investigate the risk factor of myocardial infarction. ROC (receiver operating characteristic) curve was used to analyze the diagnostic performance of Gas6 to AMI. Results The levels of Gas6 in angina pectoris group [13.77 (10.57-17.03) ng/ ml, t=2.444, P=0.025] and AMI group[16.22 (12.70-20.09) ng/ml, t=4.965, P<0.001] was higher than control group [10.92 (8.90-14.92) ng/ml]. The levels of Gas6 in angina pectoris group was lower than AMI group (t=3.854, P<0.001). In the sensitivity analysis excluding hypertension and diabetes, the serum Gas6 level in AMI group (n=37) [15.05 (11.08-16.20) mg/L] was higher than that in control group [10.93 (8.91-14.93)mg/L, t=3.479, P=0.001] and angina group (n=42) [12.85 (9.10-16.20) mg/L, t=2.639, P=0.019]. CRP (C-reactive protein), WBC (white blood cell count), Glu (fasting glucose) and Cr (creatinine) were positively correlated with Gas6, r=0.194, 0.176, 0.180 and 0.120, P value=0.010, 0.012, 0.010 and 0.002, respectively. Logistic regression showed that Gas6 was a independent factor of myocardial infarction [OR and 95%CI were 1.080 (1.012-1.152), P=0.020]. AUC and 95%CI of ROC curve was 0.648 (0.572-0.723). Conclusion The levels of Gas6 may be positively associated with myocardial infarction risk. Key words: Acute myocardial infarction; Inflammation; Growth arrest-specific protein 6

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生长抑制特异性蛋白6与急性心肌梗死关系的研究

目的探讨生长抑制特异性蛋白6 (Gas6)与急性心肌梗死(AMI)的关系。方法选取武汉大学人民医院2018年1 - 6月收治的患者。103例心绞痛患者(年龄60.20±9.35岁)作为心绞痛组。AMI组共102例，年龄58.85±9.80岁。健康对照130例，年龄63.14±10.40岁。采用Spearman分析探讨Gas6与冠心病危险因素的相关性。采用Logistic回归分析心肌梗死的危险因素。采用受试者工作特征曲线(ROC)分析Gas6对AMI的诊断效果。结果心绞痛组Gas6水平[13.77 (10.57 ~ 17.03)ng/ml, t=2.444, P=0.025]和AMI组[16.22 (12.70 ~ 20.09)ng/ml, t=4.965, P<0.001]均高于对照组[10.92 (8.90 ~ 14.92)ng/ml]。心绞痛组Gas6水平低于AMI组(t=3.854, P<0.001)。在排除高血压和糖尿病的敏感性分析中，AMI组(n=37) [15.05 (11.08-16.20) mg/L]高于对照组[10.93 (8.91-14.93)mg/L, t=3.479, P=0.001]和心绞痛组(n=42) [12.85 (9.10-16.20) mg/L, t=2.639, P=0.019]。CRP (c -反应蛋白)、WBC(白细胞计数)、Glu(空腹血糖)和Cr(肌酐)与Gas6呈正相关，r分别为0.194、0.176、0.180和0.120,P值分别为0.010、0.012、0.010和0.002。Logistic回归分析显示，Gas6是心肌梗死的独立因素[OR和95%CI为1.080 (1.012-1.152)，P=0.020]。ROC曲线的AUC和95%CI为0.648(0.572 ~ 0.723)。结论Gas6水平与心肌梗死风险呈正相关。关键词:急性心肌梗死;炎症;生长抑制特异性蛋白

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