In Elimination Settings, Measles Antibodies Wane After Vaccination but Not After Infection: A Systematic Review and Meta-Analysis.

The Indonesian Journal of Infectious Diseases Pub Date : 2022-09-28 DOI:10.1093/infdis/jiac039

Shelly Bolotin, Selma Osman, Stephanie L Hughes, Archchun Ariyarajah, Andrea C Tricco, Sumaiya Khan, Lennon Li, Caitlin Johnson, Lindsay Friedman, Nazish Gul, Rachel Jardine, Maryrose Faulkner, Susan J M Hahné, Jane M Heffernan, Alya Dabbagh, Paul A Rota, Alberto Severini, Mark Jit, David N Durrheim, Walter A Orenstein, William J Moss, Sebastian Funk, Nikki Turner, William Schluter, Jaleela S Jawad, Natasha S Crowcroft

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引用次数: 0

Abstract

Background: We conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings.

Methods: After screening 16 822 citations, we identified 9 articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria.

Results: Using linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received 2 doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% confidence interval [CI], -212.4 to -31.1) per year since vaccination over 1 to 5 years, 53.7 mIU/mL (95% CI, -95.3 to -12.2) 5 to 10 years, 33.2 mIU/mL (95% CI, -62.6 to -3.9), 10 to 15 years, and 24.1 mIU/mL (95% CI, -51.5 to 3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after 1 dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after 1 or 2 doses of MCV or after infection.

Conclusions: Measles antibody waning in vaccinated populations should be considered in planning for measles elimination.

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在消除环境中，麻疹抗体在接种疫苗后减弱，但在感染后不会减弱：一项系统综述和荟萃分析。

背景：我们进行了一项系统综述，以评估在麻疹消除环境中，以前感染或接种过麻疹疫苗的人群中麻疹体液免疫是否会减弱。方法：在筛选了16822篇引文后，我们从暴露于野生型麻疹的人群中确定了9篇文章，从接种疫苗的人群中确定了16篇符合我们的纳入标准的文章。结果：使用线性回归，我们发现接种2剂含麻疹疫苗（MCV）的个体的几何平均滴度（GMTs）在接种后1至5年内每年显著下降121.8 mIU/mL(95%置信区间[CI]， -212.4至-31.1)，接种后5至10年每年下降53.7 mIU/mL (95% CI, -95.3至-12.2)，接种后15至20年每年下降33.2 mIU/mL (95% CI, -62.6至-3.9)，10至15年每年下降24.1 mIU/mL （95% CI, -51.5至3.3）。1剂MCV或感染后，GMT随时间的降低不显著。在1或2剂MCV或感染后，随着时间的推移，血清阳性个体比例的下降并不显著。结论：麻疹疫苗接种人群的麻疹抗体下降应在计划消灭麻疹时予以考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Indonesian Journal of Infectious Diseases

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