STUDY THE IMPACT OF ANTIVENOM OF Echis carinatus SNAKE ON BLOOD PARAMETER, ENZYMES AND SEX HORMONES PARAMETERS IN WISTER AlBINO MALE RATS

University of Thi-Qar Journal Pub Date : 2019-04-24 DOI:10.32792/utq/utj/vol13/1/4

B. R. Ali, S. Enayah, K. Al-Fartosi

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Abstract

In the current study the authors aimed to investigate the effect of anti-venom of Echis carinatus on hematological and hormones parameters as well as explore its influence on liver enzymes of male rats. Mature adult rats were divided into three groups 6 animals for each group. IP injected method was used. First group (Control group) injected with normal saline (0.9%Nacl), Two group injected with (0.25ml/kg) of anti-venom for two times, and the third group injected with (0.5ml/kg) of antivenom for two times. Animals killed within 24 h. The outcome of the current study showed that there are statistically different in RBC, MCH, MCHC, PCV, MCV, total WBC, lymphocytes, monocytes and granulocytes among second and third groups compared with control group (P≤0.05). In addition, the results show a significant increasing the number of platelets and liver enzymes ALT, AST, ALP in the highly-treated group comparing with the control. Also, level of FSH, LH and testosterone likewise increased in the treated groups comparing with control. Anti-venom reduced sperm count in male rats.

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摘要研究蛇抗蛇毒液对白化雄性大鼠血液指标、酶及性激素指标的影响

本研究旨在探讨鱼鳗抗蛇毒对雄性大鼠血液学和激素参数的影响，以及对肝酶的影响。将成年大鼠分为3组，每组6只。采用IP注射法。第一组(对照组)注射生理盐水(0.9%Nacl)，第二组注射(0.25ml/kg)抗蛇毒血清2次，第三组注射(0.5ml/kg)抗蛇毒血清2次。本研究结果显示，第二组和第三组的红细胞、MCH、MCHC、PCV、MCV、总白细胞、淋巴细胞、单核细胞和粒细胞与对照组相比有统计学差异(P≤0.05)。此外，结果显示，与对照组相比，高剂量治疗组血小板数量和肝酶ALT、AST、ALP显著增加。此外，与对照组相比，治疗组的FSH、LH和睾酮水平也同样升高。抗蛇毒血清减少了雄性大鼠的精子数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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University of Thi-Qar Journal

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