A new neutral-lipophilic 99mTc complex with a bis-hydrazide-phosphine (BHP) ligand

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-09-01 DOI:10.1016/0883-2889(92)90059-N

K.V. Katti , P.R. Singh , W.A. Volkert , A.R. Ketring , K.K. Katti

引用次数: 8

Abstract

A new bis-hydrazide-phosphine (BHP) ligand was synthesized, characterized and complexed with ^99mTc. ^99mTc phenyl-BHP (PBHP) was shown to form a neutral-lipophilic chelate with ^99mTc, in high yields, that is stable over a wide pH range. Results with ^99mTc-PBHP indicate that the BHP chelating moiety is attractive for use in designing new ^99mTc-imaging agents.

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一种新的含双肼膦(BHP)配体的中性亲脂性99mTc配合物

合成了一种新的双肼膦(BHP)配体，对其进行了表征并与99mTc络合。99mTc苯基必和必(PBHP)与99mTc形成中性亲脂螯合物，产率高，且在较宽的pH范围内稳定。99mTc-PBHP的结果表明，BHP螯合部分在设计新的99mtc显像剂方面具有吸引力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes

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