Effect of Exercise on Fasting Blood Glucose and Oral Glucose Tolerance Tests In Offspring of Type 2 Diabetic and Non-Diabetic Parents

E. Taiwo.
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引用次数: 2

Abstract

Objectives: It is uncertain if exercise could influence the occurrence of T2DM in offspring of diabetic parents. Therefore this study was designed to assess the effect of exercise on fasting blood glucose and oral Glucose Tolerance Test on offspring of T2DM parents compared with offspring of non-diabetic parents. Design: This study involved selection of 10 offspring of T2DM parents attending University College Hospital, Ibadan and 10 offspring of non-diabetic parents who are undergraduate students of the University of Ibadan, Nigeria. Participants were randomly assigned into four groups: 5 Normal-weight Offspring of Non-Diabetic Parents (NONDP), 5 Normal-weight Offspring of Diabetic Parents (NODP), 5 Overweight Offspring of NonDiabetic Parents (OONDP) and 5 Overweight Offspring of Diabetic Parents (OODP). Each participant followed a protocol of graded exercise using the tummy trimmer everyday spending 30-45 minutes daily for 24 weeks. Blood samples were obtained after an overnight fasting for determination of fasting blood glucose using standard methods at baseline, six week, 12 week, 18 week and 24 week, respectively. Data were analyzed using descriptive statistic and repeated ANOVA with significant at P<0.05. Results: At baseline, Oral GTT were also carried out before the beginning of exercise and repeated at the end of 24 weeks of exercise. There were reductions though not significant in fasting blood glucose (mg/dL) viz in NONDP: 91.00±3.71to 84.50±3.34, NODP: 100.67±3.75to88.17±0.75, OONDP:93.67±5.82 to87.17±4.98 and OODP 90.83±5.25to82.83±2.37 at 24weeks. Conclusions: Graded exercise reduced fasting blood glucose in all the groups. The clinical importance of graded exercise in prevention of diabetes mellitus among offspring of diabetic parents is a useful intervention.
运动对2型糖尿病和非糖尿病父母后代空腹血糖和口服糖耐量试验的影响
目的:尚不清楚运动是否会影响糖尿病父母的后代发生2型糖尿病。因此,本研究旨在评估运动对T2DM父母后代空腹血糖和口服葡萄糖耐量试验的影响,并与非糖尿病父母后代进行比较。设计:本研究选取10例在伊巴丹大学学院医院就诊的2型糖尿病父母的子女和10例在尼日利亚伊巴丹大学就读的非糖尿病父母的子女。参与者被随机分为4组:5名非糖尿病父母体重正常的后代(NONDP), 5名糖尿病父母体重正常的后代(NODP), 5名非糖尿病父母超重的后代(OONDP)和5名糖尿病父母超重的后代(OODP)。在24周的时间里,每位参与者都遵循了一项分级锻炼方案,每天使用腹部修整器进行30-45分钟的锻炼。禁食一夜后采集血样,分别在基线、6周、12周、18周和24周采用标准方法测定空腹血糖。资料分析采用描述性统计和重复方差分析,P<0.05为显著性差异。结果:在基线时,口服GTT也在运动开始前进行,并在24周运动结束时重复。24周时,空腹血糖(mg/dL)(即:NODP: 91.00±3.71至84.50±3.34,NODP: 100.67±3.75至88.17±0.75,OONDP:93.67±5.82至87.17±4.98,OODP: 90.83±5.25至82.83±2.37)降低,但无显著性差异。结论:分级运动降低了各组的空腹血糖。分级运动对糖尿病父母后代预防糖尿病的临床意义是一种有益的干预措施。
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