The Combination of Sufentanil and Remifentanil on Hemodynamic Changes during Anesthetic Induction and Endotracheal Intubation

Abstract

The of and on Hemodynamic Changes during Anesthetic Induction and Intubation. Abstract Introduction: A low dose of sufentanil was insufficient to suppress endotracheal intubation (ETI) induced cardiovascular response. This study investigated the effects of combined sufentanil and remifentanil on hemodynamic changes during anesthetic induction and ETI. Methods: 70 adult patients were divided into two groups (n = 35). General anesthesia was induced by sufentanil, propofol, and cisatracurium. Group S received sufentanil 0.3 mcg/kg, while Group R received sufentanil 0.3 mcg/kg and remifentanil 1 mcg/kg. The systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), and heart rate (HR), incidence and severity of hypotension, hypertension, bradycardia, and tachycardia, doses of propofol during anesthetic induction and ETI were compared. Results: After anesthetic induction, the changes of SAP, DAP, MAP and HR were comparable between the groups ( p > 0.05). Right after ETI, the HR in Group R was significantly lower than Group S ( p < 0.001). 5 min after ETI, the SAP, DAP, and MAP in Group R was significantly higher than Group S ( p < 0.03). The incidence and severity of hypotension, hypertension, bradycardia, and tachycardia was comparable between the groups ( p > 0.07). The dose of propofol used in Group R was significantly lower than Group S ( p = 0.001). and remifentanil is superior to sufentanil alone for attenuating ETI induced cardiovascular response without cardiovascular compromise.