Exploring Pharmacological Potentials of p-Coumaric Acid: A Prospective Phytochemical for Drug Discovery

A. Zaman, H. Hasnat, Z. Noman, M. M. Islam, Abdullah Al Nakib, Swakshar Mukherjee, Kabbo Saha, N. U. Ahmed, S. Ashrafi, Tanoy Saha, Md. Ashraful Islam, Safaet Alam
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Abstract

p-coumaric acid, commonly referred to as 4-hydroxycinnamic acid, is a phenolic acid, which has been subjected to much research in recognition of its beneficial properties against several diseases and its widespread distribution in the plant kingdom. This compound can be found in the free-state or coupled with other molecules in nature. It has demonstrated prospective pharmacological effects including antiproliferative, nephroprotective, neuroprotective, antioxidant and antimicrobial effects in addition to other biological properties through numerous in vivo, in vitro and clinical studies. This review reported a short summary on p-coumaric acid to provide fundamental information in its biosynthesis, plant sources, and pharmacological effects which may help in future research and development of novel therapeutics. Bangladesh Pharmaceutical Journal 26(2): 185-194, 2023 (July)
探索对香豆酸的药理学潜力:一种有前景的植物化学药物发现
对香豆酸,通常被称为4-羟基肉桂酸,是一种酚酸,由于其对几种疾病的有益特性及其在植物界的广泛分布,已受到许多研究。这种化合物可以在自然界中以自由状态存在或与其他分子偶联。通过大量的体内、体外和临床研究,它已经证明了其潜在的药理作用,包括抗增殖、肾保护、神经保护、抗氧化和抗菌作用以及其他生物学特性。本文就对香豆酸的生物合成、植物来源、药理作用等方面的研究进展作一综述,以期为今后对香豆酸的研究和开发提供参考。孟加拉国医药杂志26(2):185- 194,2023(7月)
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