Efficacy and safety of febuxostat in renal transplant recipients with hyperuricemia

Chineae Journal of Organ Transplantation Pub Date : 2019-03-20 DOI:10.3760/CMA.J.ISSN.0254-1785.2019.03.008

Jiajia Jiang, Q. Fu, Sizhe Long, Huanxi Zhang, Xiaojun Su, Jun Li, Chenglin Wu, R. Deng, Longshan Liu, Wujun Zhang, Changxi Wang

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引用次数: 1

Abstract

Objective To assess the efficacy and safety of febuxostat in the treatment of hyperuricemia in renal transplant recipients. Methods A total of 124 renal transplant patients with hyperuricemia receiving febuxostat between June 2016 and July 2018 were retrospectively analyzed. Uric acid (UA), liver function and renal function parameters before and 3 months after treatment were compared. Adverse events, recipient and renal allograft survival were recorded throughout the follow-up period. Results Serum level of uric acid significantly decreased after 3-month treatment (P<0.001). And 66.1 % of them achieved target UA level at Month 3 after dosing. Estimated glomerular filtration rate (eGFR) was maintained. No severe adverse event was observed. All recipient and renal grafts survived during the follow-up period. Conclusions Febuxostat is both effective and safe in the treatment of hyperuricemia in renal transplant. Key words: Renal transplantation; Hyperuricemia; Efficacy

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非布司他治疗肾移植受者高尿酸血症的疗效和安全性

目的评价非布司他治疗肾移植术后高尿酸血症的疗效和安全性。方法回顾性分析2016年6月至2018年7月接受非布司他治疗的124例高尿酸血症肾移植患者。比较治疗前和治疗后3个月的尿酸、肝功能、肾功能参数。在整个随访期间记录不良事件、受体和同种异体肾移植存活。结果治疗3个月后血清尿酸水平明显降低(P<0.001)。66.1%的患者在给药后第3个月达到目标UA水平。维持估计的肾小球滤过率(eGFR)。未观察到严重的不良事件。在随访期间，所有受体和肾移植均存活。结论非布司他治疗肾移植术后高尿酸血症安全有效。关键词:肾移植;高尿酸血;功效

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Chineae Journal of Organ Transplantation

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