Characteristics of antioxidant and NO-synthase systems of blood lymphocytes under the action of decamethoxine

Abstract

Antiseptic drugs have mostly microbicidal effect on the skin surface, mucous membranes, surfaces of a wound and body cavities. Decamethoxine is a chemical compound [1, 10-decameth-ylene bis (N, N – dimethylmethoxycarbonylmethyl) ammonium dichloride] that has a wide range of antimicrobial actions on Gram - positive (staphylococcus, streptococcus, pneumococcus), Gram-negative (gonococcus, meningococcus) cocci, diphtheria corynebacteria, enterobacteria, pseudomonads, protozoa, dermatophytes, yeasts-like fungi of the genus Candida , chlamydia and viruses. Pathological processes that occur in the cells of the body when inflammatory processes and pathological conditions are caused primarily by the violation of regulatory systems, the activation of lipid peroxidation processes and the violation of antioxidant protective system. Since decamethoxine has hydrophilic and lipophilic properties, it can penetrate into cells, blood through surfaces of a wound, mucous membranes, skin, etc., and be transmitted by blood to different organs and tissues, thus causing a variety of biochemical effects, particularly regarding to the regulatory NO-synthase system of cells. In this respect the biological action of decamethoxine nisms of the cell, blood lymphocytes in particular. It activates the enzymes of the glutathione antioxidant system, stimulates the activity of arginase and inhibits the activity of the constitutive isoform of NO synthase with the simultaneous activation of the inducible isoform of NO synthase.