Metabolic Syndrome in Patients with Gallstone

Abstract

Background: Metabolic Syndrome (MetS) is defined as a cluster of multiple cardiovascular risk factors, including central obesity, elevated fasting plasma glucose, high blood pressure, dyslipidemia. The prevalence of MetS has been increasing gradually in the world and there are many hypotheses about relationship between metabolic syndrome and others diseases. The aim of this study is evaluation of prevalence of metabolic syndrome in the patients with gallstone disease. Methods and materials: 400 patients with gallstone disease entered in a cross sectional study. Medical files were extracted and metabolic syndrome was defined by Adult Treatment Panel III (ATP III) base on clinical data. Results: Metabolic syndrome was diagnosed in 213 (53.3%) subjects. In this group, 175 (82.2%) had their gallstone both in gall bladder and biliary tract and 38 (17.85) only in biliary tract. In patients without metabolic syndrome, 127 (67.9%) had the gallstone in both gallbladder and biliary tract and 60 (32.1%) only in their biliary tract. Comparison of these ratios led to a statistically significant difference (P=0.001; Odds Ratio: 2.18; CI 95%: 1.36-3.47). Conclusions: The results showed that may be a relationship between metabolic syndrome and gallstone disease. More future study with control group for this evaluation is necessary.