Biphasic action of ethanol

L.A. Pohorecky
{"title":"Biphasic action of ethanol","authors":"L.A. Pohorecky","doi":"10.1016/0147-7552(77)90025-0","DOIUrl":null,"url":null,"abstract":"<div><p>Physiological, behavioral, and biochemical evidence demonstrating the excitatory and depressant effects of ethanol in man and experimental animals is reviewed. An excitatory action is noted on exposure of an organism to low doses of ethanol. Thus stimulatory effects of ethanol on motor activity, various behaviors, EEG activation, and gastric acid secretion are well documented. A stimulatory effect of ethanol is also noted as a delayed response (after 7–18 hr) with large doses of ethanol. Examples here include seizure susceptibility, some neurotransmitter mechanisms (norepinephrine, acetylcholine), and sensitivity to pain. It is likely that differences in dosage and of the time of observation after ethanol treatment have contributed to some extent to the variability of results reported in the literature. Some implications and possible mechanisms for the biphasic actions of ethanol are discussed.</p></div>","PeriodicalId":100157,"journal":{"name":"Biobehavioral Reviews","volume":"1 4","pages":"Pages 231-240"},"PeriodicalIF":0.0000,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0147-7552(77)90025-0","citationCount":"357","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biobehavioral Reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0147755277900250","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 357

Abstract

Physiological, behavioral, and biochemical evidence demonstrating the excitatory and depressant effects of ethanol in man and experimental animals is reviewed. An excitatory action is noted on exposure of an organism to low doses of ethanol. Thus stimulatory effects of ethanol on motor activity, various behaviors, EEG activation, and gastric acid secretion are well documented. A stimulatory effect of ethanol is also noted as a delayed response (after 7–18 hr) with large doses of ethanol. Examples here include seizure susceptibility, some neurotransmitter mechanisms (norepinephrine, acetylcholine), and sensitivity to pain. It is likely that differences in dosage and of the time of observation after ethanol treatment have contributed to some extent to the variability of results reported in the literature. Some implications and possible mechanisms for the biphasic actions of ethanol are discussed.

乙醇的双相作用
综述了乙醇在人体和实验动物中的兴奋和抑制作用的生理、行为和生化证据。当生物体暴露于低剂量乙醇时,可观察到兴奋作用。因此,乙醇对运动活动、各种行为、脑电图激活和胃酸分泌的刺激作用已被充分证明。大剂量乙醇的刺激作用还表现为延迟反应(7-18小时后)。这里的例子包括癫痫易感性、一些神经递质机制(去甲肾上腺素、乙酰胆碱)和对疼痛的敏感性。很可能是剂量和乙醇处理后观察时间的差异在一定程度上导致了文献中报道的结果的可变性。讨论了乙醇双相作用的一些意义和可能的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信