Association of different biomarkers and CT value of RT-PCR with mortality in COVID-19 cases attended at tertiary care centre in India

Abstract

Background: Severe Acute Respiratory Syndrome- Corona Virus-2 (SARS-CoV-2) infection becomes the pandemic of coronavirus disease 2019 (COVID-19) shows drastic changes in health care system. Aims and objectives: (1) To assess different biomarkers in COVID-19 cases, (2) To correlate biomarkers with cycle threshold (CT) value of Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and it's role for prognosis of severe cases. Material and Methods: Consecutive patients with positive for SARS-CoV-2 by RT-PCR with CT value less than 36 were included. A CT values were found for envelope (E-gene) as a screening gene and RNA dependent RNA polymerase (RdRp) as a confirmatory gene were amplified during RT-PCR. The severity of illness was assessed using different biochemical parameters for C-reactive protein (CRP), serum ferritin, D-dimer, lactate dehydrogenase (LDH), serum urea, and creatinine.