Studies on synergistic effect of Mormodica charantia, Ocimum sanctum and Prosopis juliflora leaves extract against some clinical isolates of bacteria

Advance Pharmaceutical Journal Pub Date : 2020-08-01 DOI:10.31024/apj.2020.5.3.2

Abubakar Dabo Dalhat, D. W. Taura, D. A. Musa, S. Ayuba, M. Shu’aibu, A. U. Muhammad

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Abstract

Objective: Aim of present study synergistic antibacterial eﬀect of and Mormodica charantia, Ocimum sanctum Prosopis juliﬂora. Material and methods: Aqueous and methanol extracts of leaves of three important medicinal plant species, and has been tested individually and in Mormodica charantia, Ocimum sanctum Prosopis juliﬂora combination for their antibacterial activity against Staphylococcus aureus, using agar well diﬀusion method. Results and conclusion: Results showed higher antibacterial activity in combination of extracts of the medicinal plants studied. The methanolic leaf extracts of and aqueous leaf extracts of showed 2.1 and P. juliﬂora M. charantia 1.9 cm zone of inhibition (ZI), respectively against and while tested individually. Whereas, the S. aureus S. pyogens combination of methanolic leaf extracts of and M. charantia P. juliﬂora M. charantia O. Sanctum showed 2.3 cm ZI against respectively. Similarly, the highest antibacterial activity of 2.5 cm S. aureus and S. Pyogens ZI was observed against in combination of methanolic leaf extracts (2:1:1) of all the three plants. This S. Pyogens study clearly demonstrates the synergistic activity of plant extracts against diﬀerent bacteria.

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苦瓜、桑麻和豆豆叶提取物对临床分离菌增效作用的研究

目的:研究苦瓜、刺槐的协同抑菌作用。材料与方法:采用琼脂孔扩散法，对三种重要药用植物叶片的水提液和甲醇提取液进行了对金黄色葡萄球菌的抑菌活性的测试，并分别在Mormodica charantia, Ocimum sanctum Prosopis juliflora组合中进行了测试。结果与结论:与所研究的药用植物提取物联合使用具有较高的抑菌活性。单独试验时，黄连叶甲醇提取物和水提物对黄连叶的抑制区分别为2.1 cm和1.9 cm。而金丝酵母菌(M. charantia P. juliflora M. charantia O. Sanctum)与金丝酵母菌(M. charantia O. Sanctum)的甲醇叶提取物组合对金黄色葡萄球菌(S. pypygens)的ZI分别为2.3 cm。同样，3种植物的甲醇叶提取物(2:1:1)组合对2.5 cm金黄色葡萄球菌和Pyogens ZI的抑菌活性最高。该研究清楚地证明了植物提取物对不同细菌的协同作用。

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Advance Pharmaceutical Journal

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