Antifungal Effects of PC945, a Novel Inhaled Triazole, on Candida albicans Pulmonary Infection in Immunocompromised Mice

Abstract

Candida spp. are often detected from fungal cultures or mycobiome analysis of respiratory secretions, but are not usually treated since, even if detected persistently, the presence is assumed to be benign colonization unless invasive candidiasis in deeply immunocompromised subjects is suspected. Thus, although antifungal therapy is standard treatment for Candida infections observed in other organs such as the vagina and skin, no practical guidelines to treat Candida infection in the respiratory tract, except for invasive candidiasis, have been developed [1,2]. Abstract