Pediatric Cushing Syndrome; an Overview.

4区医学 Q2 Medicine

Pediatric endocrinology reviews : PER Pub Date : 2019-12-01 DOI:10.17458/per.vol17.2019.ts.pediatriccushingsyndrome

C. Tatsi, C. Stratakis

引用次数: 3

Abstract

Endogenous Cushing syndrome (CS) is a rare entity in the pediatric population. Patients usually present with height deceleration and continuous weight gain, along with other classic stigmata of CS, such as acne, striae, hirsutism and others. The diagnosis of CS involves documentation of abnormal cortisol secretion with measurement of urinary free cortisol and midnight serum or salivary cortisol, and the use of the 1mg dexamethasone suppression test. After confirmation of CS, localization of the source of hypercortisolemia, involves differentiation of ACTH-dependent versus ACTH-independent causes of CS. Surgical resection of the identified source of CS is the preferred method of treatment whenever possible.

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儿童库欣综合征;概述。

内源性库欣综合征(CS)在儿科人群中是一种罕见的疾病。患者通常表现为身高下降，体重持续增加，并伴有其他典型的CS的柱头，如痤疮，条纹，多毛等。CS的诊断包括通过测量尿游离皮质醇和午夜血清或唾液皮质醇来记录异常皮质醇分泌，并使用1mg地塞米松抑制试验。CS确诊后，高皮质血症来源的定位涉及到CS的acth依赖型和acth非依赖型病因的分化。手术切除已确定的CS来源是治疗的首选方法，只要可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism

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期刊介绍： PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.