Histological Study of the Possible Protective Effect of Spirulina platensis on Dibutyl Phthalate (DBP)-induced Pulmonary Alveolar Changes in Adult Male Albino Rats

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-06-30 DOI:10.13005/bpj/2674

Aiman Al-Maathidy, ,Fardous Karawya, Samer Y. Al-Qaraleh, Aiman Al Qtaitat

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引用次数: 0

Abstract

Background: Phthalates are known to be major environmental hazards. Dibutyl phthalate (DBP), a commonly used phthalate ester, is present in a variety of products. Humans can be exposed to DBP from various sources, which can release it into biological fluids and cause various health problems by penetrating different tissues in the body. Aims: The aim of this study was to investigate the effects of DBP on pulmonary alveoli in rats and to assess the mitigating influence of S. platensis. Methods: The study involved 30 young adult male albino rats, which were divided into 3 groups (n = 10 each): control, group II (rats treated with phthalate ester (DBP; 50 mg/kg body weight/day)), and group III (Spirulina-protected animals given phthalate ester (DBP; 50 mg/kg body weight + Spirulina (200 mg/kg body weight/day)). Results: The study revealed that alveolar tissues in the groups treated with DBP showed significant increases in collagen deposition and inflammatory cellular infiltration. Furthermore, the numbers of type-II pneumocytes and alveolar macrophages were significantly increased. However, most of these effects were ameliorated by Spirulina platensis. Conclusion: These findings suggest that Spirulina may have potentially beneficial effects on pulmonary alveoli by mitigating the toxic effects of DBP.

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螺旋藻对邻苯二甲酸二丁酯(DBP)诱导的成年雄性白化大鼠肺泡变化保护作用的组织学研究

背景:邻苯二甲酸盐是已知的主要环境危害。邻苯二甲酸二丁酯(DBP)是一种常用的邻苯二甲酸酯，存在于各种产品中。人类可以从各种来源接触到DBP, DBP可以释放到生物体液中，并通过穿透身体的不同组织引起各种健康问题。目的:研究舒张压(DBP)对大鼠肺泡的影响，并评价肺棘球蚴(S. platensis)的缓解作用。方法:选取30只年轻成年雄性白化病大鼠，随机分为3组，每组10只:对照组，II组(邻苯二甲酸酯(DBP);50 mg/kg体重/天))，第三组(螺旋藻保护动物给予邻苯二甲酸酯(DBP;50毫克/公斤体重+螺旋藻(200毫克/公斤体重/天))。结果:DBP治疗组肺泡组织胶原沉积和炎性细胞浸润明显增加。ii型肺细胞和肺泡巨噬细胞数量明显增加。然而，这些效应大部分被螺旋藻所改善。结论:这些发现提示螺旋藻可能通过减轻舒张压的毒性作用而对肺泡有潜在的有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.