To Study the Effect of Beta Antagonist Esmolol on Bispectral Index and Arm Movement During Intubation

Abstract

Background and Aims: Bispectral index response(BIS) reflects cerebral cortical activity and is an important pharmacodynamic parameter of anaesthetic effects on central nervous system. The prospective double blinded controlled study was undertaken to study effect of beta-1 antagonist esmolol on BIS, arm movement during intubation. Methods: Fifty adult patients aged 18 to 60 years scheduled for elective non-cardiac, non-cranial surgery surgery under general anaesthesia were undertaken for the study. Randomisation was done using closed envelope method. Data was analysed with Stat-View (Version 18, SPSS). Chi-square test was used to compare percentage of patients with arm movement. Results: Demographic variables age, weight, intubation duration, sex had P-value greater than 0.05. Arm movement was observed in 40% of patients in Esmolol group against 84% patients in Control group. T-value was below 0.05. Conclusion: Addition of esmolol leads to attenuation of haemodynamic, arm movements and BIS increase in response to intubation.