ANTIDIABETIC POTENTIAL OF PERSIMMON PULP POWDER ON ALLOXAN INDUCED DIABETIC RABBITS

Abstract

Diabetes, a condition when blood glucose level goes beyond the normal range. Natural treatments particularly through bioactive components from fruit and vegetable sources are becoming popular worldwide and are broadly accepted because of no side effects and cost effectiveness. The present study was planned to investigate the antidiabetic potential of persimmon pulp powder by using alloxan induced diabetic rabbits as an animal model. For this purpose, fifteen rabbits were induced Diabetes mellitus by alloxan and divided into three groups. Persimmon pulp powder supplemented diets (0%, 10% and 20%) were given to the diabetic rabbits for the duration of 21 days. The blood samples of rabbits were examined for glucose, serum creatinine and urea levels on weekly basis. The results indicated that there was a significant decline in glucose as well as creatinine and urea levels in blood of diabetic rabbits. The reduction of blood glucose level was ranged from 357.66 mg/dL to 256.45 mg/dL on administration of 20% persimmon peel powder in the feed of rabbits. Similarly, serum creatinine and urea levels were also significantly reduced 1.42 mg/dl and 1.22 mg/dl and 47.50 mg/dl and 24.22 mg/dl, respectively because of supplementation of 20% persimmon pulp powder. It is concluded from the results that persimmon pulp powder might be a potential natural antidiabetic treatment of diabetic complications.