Comparative Evaluation of Clonidine and Fentanyl as Adjuvants with Levobupivacaine for Postoperative Epidural Analgesia after Total Knee Replacement Surgery - A Randomised Double Blind Study

IF 0.1 Q4 ANESTHESIOLOGY

Pediatric Anesthesia and Critical Care Journal Pub Date : 2022-01-01 DOI:10.26502/acc.032

Madhukant ., Subhash Chandra, Rohit Kateliya, P. Kumari, C. Sinha, J. Kaur

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Abstract

Comparative Evaluation of Clonidine and Fentanyl as Adjuvants with Levobupivacaine for Postoperative Epidural Analgesia after Total Knee Replacement Surgery - A Randomised Double Blind Study. Anesthesia and Critical Care Abstract Background and Aims Epidural anaesthesia commonly used for inducing anaesthesia and postoperative analgesia in patients undergoing lower limb surgeries. Fentanyl as an adjuvant to epidural local anesthetic has been for long time. Clonidine is a potent and selective α-2-adrenoceptor agonist with analgesic potency. The aim of the study was to compare the effect of clonidine and fentanyl as an adjuvant to epidural levobupivacaine in total knee replacement surgery. total knee randomly divided into two groups. Patients were allocated to one of the two groups by computer generated random selection. Group I (n=35) patients received postoperative continuous epidural infusion of levobupivacaine (1.25mg/ml) with fentanyl (2 μg/ml) whereas Group II (n=35) patients received epidural infusion of Levobupivacaine (1.25mg/ml) with Clonidine (1μg/ml) in the range of 3-7 ml/hr.

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全膝关节置换术术后硬膜外镇痛辅助剂克拉定、芬太尼与左布比卡因的比较评价——一项随机双盲研究

全膝关节置换术术后硬膜外镇痛辅助剂克拉定、芬太尼与左布比卡因的比较评价——一项随机双盲研究。背景与目的硬膜外麻醉常用于下肢手术患者的诱导麻醉和术后镇痛。芬太尼作为硬膜外局麻的辅助剂已有很长时间。可乐定是一种有效的选择性α-2肾上腺素能受体激动剂，具有镇痛作用。该研究的目的是比较氯定和芬太尼作为硬膜外左布比卡因辅助全膝关节置换术的效果。全膝关节随机分为两组。通过计算机生成的随机选择将患者分配到两组中的一组。第一组(n=35)术后连续硬膜外输注左布比卡因(1.25mg/ml)与芬太尼(2 μg/ml)，第二组(n=35)术后连续硬膜外输注左布比卡因(1.25mg/ml)与氯定(1μg/ml)，输注范围为3 ~ 7 ml/hr。

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来源期刊

Pediatric Anesthesia and Critical Care Journal ANESTHESIOLOGY-

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审稿时长

4 weeks