Factors affecting blood pressure in patients with arterial hypertension and subclinical hypothyroidism

Abstract

Background: The aim our study was to find factors affecting blood pressure in patients with arterial hypertension (AH) and subclinical hypothyroidism (SH). Material and methods: 138 patients aged from 25 to 59 years were examined and divided into control group (n=30), euthyroid patients with AH (n=45) and patients with AH in combination with SH (n=63). The levels of tumor necrosis factor-α, C-reactive protein, total hydroperoxide content, total antioxidant activity, total superoxide dismutase activity and sirtuin 1 were measured in addition to complete blood count and routine biochemical tests. The Kruskal-Wallis H test was used to test whether there was a significant difference between the independent and its dependent variables. Results: Fewer factors affected systolic and diastolic blood pressure in patients with AH and SH compared with euthyroid patients. These included age, waist circumference, insulin, triglycerides, very high density lipoprotein cholesterol, and TAA. The opposite results were found in relation to the increase in pulse pressure: significant effects of gender, hemoglobin, alkaline phosphatase were observed in patients with SH and only the level of ACT had a significant influence in euthyroid patients. Conclusions. Factors associated with the pressure and their overall number differed among patients with SH and AH compared with euthyroid patients with AH. Such results may be due to changes in anthropometric parameters, metabolic profile and oxidative status in patients with concomitant SH.