NLRP3 Inflammasome Mediated Production of Th1/Th17 Cytokines in Response to Inflammatory Stimulants in Innate Immune Cells

Abstract

Introduction: Monocytes play a major role in eliciting the immune response against infection. Also mast cells are found to play a critical role in mediating inflammatory immune response not only to allergic reaction but also to infection by inducing the production of inflammatory cytokines such as IL-1β, IL-6, IL-18 and IL-17. This study aims to investigate nod like receptor protein 3 (NLRP3) mediated production of Th1/Th17 cytokines in monocytes and mast cells.