Distinct cognitive changes in male patients with obstructive sleep apnoea without co-morbidities.

IF 4.9 4区 计算机科学 Q1 AUTOMATION & CONTROL SYSTEMS
Valentina Gnoni, Michel Mesquita, David O'Regan, Alessio Delogu, Ivan Chakalov, Andrea Antal, Allan H Young, Romola S Bucks, Melinda L Jackson, Ivana Rosenzweig
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引用次数: 0

Abstract

Introduction: Obstructive sleep apnoea (OSA) is a multisystem, debilitating, chronic disorder of breathing during sleep, resulting in a relatively consistent pattern of cognitive deficits. More recently, it has been argued that those cognitive deficits, especially in middle-aged patients, may be driven by cardiovascular and metabolic comorbidities, rather than by distinct OSA-processes, such as are for example ensuing nocturnal intermittent hypoxaemia, oxidative stress, neuroinflammation, and sleep fragmentation.

Methods: Thus, we undertook to define cognitive performance in a group of 27 middle-aged male patients with untreated OSA, who had no concomitant comorbidities, compared with seven matched controls (AHI mean ± S.D.: 1.9 ± 1.4 events/h; mean age 34.0 ± 9.3 years; mean BMI 23.8 ± 2.3 kg/m2). Of the 27 patients, 16 had mild OSA (AHI mean ± S.D.:11.7 ± 4.0 events/h; mean age 42.6 ± 8.2 years; mean BMI 26.7 ± 4.1 kg/m2), and 11 severe OSA (AHI 41.8 ± 20.7 events/h; age: 46.9 ± 10.9 years, BMI: 28.0 ± 3.2 kg/m2).

Results: In our patient cohort, we demonstrate poorer executive-functioning, visuospatial memory, and deficits in vigilance sustained attention, psychomotor and impulse control. Remarkably, we also report, for the first time, effects on social cognition in this group of male, middle-aged OSA patients.

Conclusion: Our findings suggest that distinct, OSA-driven processes may be sufficient for cognitive changes to occur as early as in middle age, in otherwise healthy individuals.

无并发症的阻塞性睡眠呼吸暂停男性患者的认知发生了明显变化。
简介阻塞性睡眠呼吸暂停(OSA)是一种多系统、使人衰弱的慢性睡眠呼吸障碍,会导致相对一致的认知障碍模式。最近,有观点认为,这些认知障碍,尤其是中年患者的认知障碍,可能是由心血管和代谢并发症引起的,而不是由独特的 OSA 过程引起的,例如随之而来的夜间间歇性低氧血症、氧化应激、神经炎症和睡眠片段化:因此,我们将 27 名未经治疗的 OSA 中年男性患者与 7 名匹配的对照组患者(AHI 平均值 ± S.D.:1.9 ± 1.4 事件/小时;平均年龄 34.0 ± 9.3 岁;平均体重指数 23.8 ± 2.3 kg/m2)进行了比较,以确定他们的认知能力。在 27 名患者中,16 人患有轻度 OSA(AHI 平均值 ± S.D.:11.7 ± 4.0 事件/小时;平均年龄 42.6 ± 8.2 岁;平均体重指数 26.7 ± 4.1 kg/m2),11 人患有重度 OSA(AHI 41.8 ± 20.7 事件/小时;年龄:46.9 ± 10.9 岁;体重指数:28.0 ± 3.2 kg/m2):在我们的患者群中,我们发现他们的执行功能和视觉空间记忆较差,并且在警觉性持续注意、精神运动和冲动控制方面存在缺陷。值得注意的是,我们还首次报告了这组男性中年 OSA 患者的社会认知能力受到的影响:我们的研究结果表明,由 OSA 驱动的独特过程可能足以使原本健康的人早在中年时就发生认知变化。
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来源期刊
International Journal of Systems Science
International Journal of Systems Science 工程技术-计算机:理论方法
CiteScore
8.00
自引率
9.30%
发文量
164
审稿时长
7.7 months
期刊介绍: International Journal of Systems Science (IJSS) is a world leading journal dedicated to publishing high quality, rigorously reviewed, original papers that contribute to the methodology and practice in emerging systems engineering themes of intelligence, autonomy and complexity. Modern systems are becoming more and more complex and sophisticated in their demand for performance, reliability and increasing autonomy. Historically, highly analytic and numeric-based methods have sufficed, frequently simplifying the problem to allow analytical tractability. Many manufactured and natural systems (biological, ecological and socio-economic) cannot be adequately represented or analyzed without requiring multiple interacting and interconnected frameworks and a common information-processing framework. A wide range of new theories, methodologies and techniques are required to ‘enable’ such systems, and thus engineering and integration to deal with these demands. IJSS therefore encourages original submissions in these areas, with special focus on papers that are strongly novel as well as not being overly applied. Proposals for special issues in cutting-edge areas of systems science are encouraged, and should be discussed with the Editor-in-Chief. Papers that cover those topics related to operations management and logistics will not be accepted for publication in IJSS. Instead they should be submitted directly to sister journal International Journal of Systems Science: Operations & Logistics. Queries regarding submissions can be made by contacting the Editor-in-Chief, whose decision is final.
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