Abstract 2601: Using chaperonin containing TCP1 as a marker to track clinically relevant circulating tumor cells

Amanda Cox, Ana C. Martini, Eunkyung Lee, R. Moroose, A. Khaled, A. Khaled
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Abstract

Current methods for assessing circulating tumor cells (CTC) in blood focus on capture and enumeration with epithelial markers that provide little information about the aggressive and invasive potential of CTC. As a result, valuable knowledge that improves monitoring of cancer recurrence and metastasis is lacking. To provide actionable information on CTC, we developed a CTC identification method based on detection of the second subunit of Chaperonin Containing TCP1 (CCT2). CCT is a macromolecular protein folding complex composed of eight subunits (CCT1-8) that drives expression of many tumorigenic factors. Bioinformatic analysis in multiple cancers, such as breast cancer, revealed increased gene expression in tumor tissue compared to normal tissue for CCT1-8 (p Citation Format: Amanda Cox, Ana Martini, Eunkyung Lee, Rebecca Moroose, Amr Khaled, Annette R. Khaled. Using chaperonin containing TCP1 as a marker to track clinically relevant circulating tumor cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2601.
2601:利用含有TCP1的伴侣蛋白作为标志物,追踪临床相关循环肿瘤细胞
目前评估血液中循环肿瘤细胞(CTC)的方法主要集中在上皮标记物的捕获和计数上,这些标记物很少提供关于CTC侵袭性和侵袭性潜力的信息。因此,缺乏改善癌症复发和转移监测的宝贵知识。为了提供可操作的CTC信息,我们开发了一种基于检测含有TCP1的伴侣蛋白第二亚基(CCT2)的CTC鉴定方法。CCT是一种由8个亚基(CCT1-8)组成的大分子蛋白质折叠复合物,它驱动许多致瘤因子的表达。生物信息学分析显示,在乳腺癌等多种癌症中,与正常组织相比,肿瘤组织中CCT1-8的基因表达增加(p引文格式:Amanda Cox, Ana Martini, Eunkyung Lee, Rebecca Moroose, Amr Khaled, Annette R. Khaled)。利用含有TCP1的伴侣蛋白作为标志物跟踪临床相关循环肿瘤细胞[摘要]。见:美国癌症研究协会2021年年会论文集;2021年4月10日至15日和5月17日至21日。费城(PA): AACR;癌症杂志,2021;81(13 -增刊):2601。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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