Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

IF 0.2 Q4 PEDIATRICS

Journal of Pediatric Epilepsy Pub Date : 2020-06-19 DOI:10.1055/s-0040-1713153

M. Mahgoob, M. Moussa

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Abstract

Abstract At least 20% of patients referred to pediatric epilepsy centers with the suspicion of epileptic seizures actually have other conditions. Neuroglobin is a new globin member which is highly expressed in the central and peripheral nervous systems. In this article, we aimed to evaluate usefulness of neuroglobin to differentiate between epilepsy and other conditions that mimic epilepsy. Our study was conducted on 90 children divided into three groups: 30 patients with epileptic seizures, 35 children with nonepileptic paroxysmal disorder, and 25 apparently healthy, age and sex-matched children as a normal control. Complete blood count, blood chemistries including random blood glucose, calcium, sodium, in addition to serum prolactin, and neuroglobin were performed for all children. This study showed a significant increase of both serum neuroglobin and prolactin levels in epileptic group compared with nonepileptic paroxysmal disorder and control groups (p < 0.01). Serum neuroglobin showed 95% sensitivity and 95.7% specificity in the diagnosis of generalized seizures. Serum neuroglobin may be a promising novel marker to differentiate epileptic versus nonepileptic disorders in children in the emergency setting, when history and clinical presentation are equivocal.

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神经球蛋白和催乳素作为鉴别儿童癫痫性与非癫痫性发作性疾病的潜在生物标志物

至少有20%的儿童癫痫中心疑似癫痫发作的患者实际上有其他疾病。神经红蛋白是在中枢和周围神经系统中高度表达的一种新的珠蛋白成员。在这篇文章中，我们的目的是评估神经红蛋白对区分癫痫和其他类似癫痫的疾病的有用性。我们的研究将90名儿童分为三组:30名癫痫发作患者，35名非癫痫性发作性障碍儿童，25名表面健康，年龄和性别匹配的正常对照儿童。对所有儿童进行全血细胞计数、血液化学成分(包括随机血糖、钙、钠、血清催乳素和神经球蛋白)检测。研究结果显示，癫痫发作组血清神经球蛋白和催乳素水平较非癫痫发作性发作障碍及对照组显著升高(p < 0.01)。血清神经球蛋白诊断全局性癫痫的敏感性为95%，特异性为95.7%。当病史和临床表现不明确时，血清神经球蛋白可能是一种有希望的新标志物，用于区分儿童癫痫与非癫痫性疾病。

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来源期刊

Journal of Pediatric Epilepsy PEDIATRICS-

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期刊介绍： The Journal of Pediatric Epilepsy is an English multidisciplinary peer-reviewed international journal publishing articles on all topics related to epilepsy and seizure disorders, epilepsy surgery, neurology, neurosurgery, and neuropsychology in childhood. These topics include the basic sciences related to the condition itself, the differential diagnosis, natural history, and epidemiology of seizures, and the investigation and practical management of epilepsy (including drug treatment, neurosurgery and non-medical and behavioral treatments). Use of model organisms and in vitro techniques relevant to epilepsy are also acceptable. Journal of Pediatric Epilepsy provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis and treatment of childhood epilepsy.