Comparative efficacy of different herbal and modern anthelmintics against gastrointestinal nematodiasis in fowl

International journal of biological research in pregnancy Pub Date : 2014-10-24 DOI:10.14419/IJBR.V2I2.3584

Md Rabiul Alam, K. J. Alam, N. Begum, M. Amin

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引用次数: 13

Abstract

The aqueous and ethanol extract of some plants and plant materials were screened for their in vitro anthelmintic effects against gastrointestinal nematodes of fowl were studied. The plant materials were extracted in distilled water (aqueous extract) and ethyl alcohol (ethanol extract). Screening of freshly prepared aqueous extract of three plant materials namely neem (Azadirachta indica), papaya (Carica papaya), korolla (Momordica charantia) and two patent drugs Eskanex® (Levamisole) and Eskapar® (Piperazine) were selected. Aqueous extracts of 25mg/ml, 50mg/ml and 100mg/ml concentration; ethanol extracts of 10mg/ml, 25mg/ml, and 50mg/ml were used for screening. Among the selected plants and patent drugs and all three concentration of aqueous extracts papaya seed was found best at 25mg/ml concentration (41%), 50mg/ml concentration (74%) and 100mg/ml (92%) followed by korolla (22%, 70% and 90% in 25mg/ml, 50mg/ml and 100mg/ml concentration respectively) against adult parasite and these plants namely papaya seed showed significant efficacy against infective larvae L3. Ethanol extracts of plants also showed significant efficacy against adult gastrointestinal worms at a concentration of 50 mg/ml. Among the selected plants and all three concentration of the ethanol extract revealed the highest efficacious plant (100%) at a concentration of 50 mg/ml. In all concentrations of ethanol extract papaya was observed as the best plant (100%, 98% and 84% at 50mg/ml, 25mg/ml and 10mg/ml concentration respectively) followed by korolla (100%, 93% and 74% at 50mg/ml, 25mg/ml and 10mg/ml concentration respectively) against adult whereas in case of larvae it showed significant efficacy. The present study suggests that papaya, korolla and neem are effective and can be used against the treatment of nematodiasis in fowl in alternative of patent drugs. More studies are needed to determine the active principles of pharmacological and toxicological assessment.

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不同草药和现代驱虫药对家禽胃肠线虫病的疗效比较

研究了几种植物和植物材料的水提物和乙醇提物对家禽胃肠道线虫的体外驱虫作用。用蒸馏水(水提液)和乙醇(乙醇提液)提取植物材料。筛选新鲜制备的印楝(Azadirachta indica)、木瓜(Carica papaya)、花冠(Momordica charantia)三种植物材料和两种专利药物Eskanex®(左旋咪唑)和Eskapar®(哌嗪)的水提物。25mg/ml、50mg/ml、100mg/ml的水提液;采用10mg/ml、25mg/ml、50mg/ml乙醇提取物进行筛选。在所选植物和专利药物中，木瓜籽水提液浓度在25mg/ml(41%)、50mg/ml(74%)和100mg/ml(92%)时对成虫的抑制效果最好，其次是花冠(25mg/ml、50mg/ml和100mg/ml分别为22%、70%和90%)，这些植物即木瓜籽对侵染幼虫L3的抑制效果显著。植物乙醇提取物在浓度为50 mg/ml时对成虫也有显著的抑制作用。在所选植物中，三种浓度的乙醇提取物均显示，浓度为50 mg/ml时，植物的有效性最高(100%)。在所有浓度的乙醇提取物中，番木瓜对成虫的效果最好(50mg/ml、25mg/ml和10mg/ml浓度分别为100%、98%和84%)，其次是花冠(50mg/ml、25mg/ml和10mg/ml浓度分别为100%、93%和74%)，对幼虫的效果显著。本研究表明木瓜、花冠和楝树是有效的，可以替代成药治疗家禽线虫病。需要更多的研究来确定药理学和毒理学评估的有效原则。

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International journal of biological research in pregnancy

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