{"title":"Exploration of the preventive effect of triamcinolone acetonide on posterior capsular opacification","authors":"Wenhuan Wang, M. Ke, Shengyu Wu, Jing Zhang","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.11.004","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the preventive effect of low concentration of triamcinolone acetonide injected in anterior chamber on posterior capsular opacification. \n \n \nMethods \nA prospective clinical randomized controlled study of 120 patients with age-related cataract which diagnosed in Department of Ophthalmology of Zhongnan Hospital of Wuhan University were selected from March 2013 to March 2014. A total of 120 cases (120 eyes) were randomly divided into two groups and performed cataract phacoemulsification. The experimental group was injected triamcinolone acetonide (4 mg/100 ml, 0.2 ml) in anterior chamber after cataract phacoemulsification while the control group was injected sodium chloride (0.9%, 0.2 ml) in anterior chamber after operation. Postoperative follow-up 36 months, the incidence of postoperative posterior capsular opacification, early preoperative inflammatory response, intraocular pressure and corneal endothelial cells count in the two groups were observed. \n \n \nResults \nAll 112 cases (112 eyes) were completed and included in the clinical analysis, including 54 cases (54 eyes) in experimental group and 58 cases (58 eyes) from control group. In the 3, 6, 12, 24 and 36 months after surgery, the incidence of postoperative posterior capsular opacification in the experimental group was lower than that in the control group (χ2=4.038, 7.377, 5.255, 4.809, 4.127, P 0.05). \n \n \nConclusions \nAnterior chamber injection of low concentration of triamcinolone acetonide is an effective and safe way which can reduce and prevent the incidence of posterior capsular opacification and delay the onset of posterior capsular opacification after cataract phacoemulsification. \n \n \nKey words: \nPosterior capsular opacification; Triamcinolone acetonide; Intraocular pressure","PeriodicalId":10236,"journal":{"name":"中国实用眼科杂志","volume":"86 1","pages":"1045-1049"},"PeriodicalIF":0.0000,"publicationDate":"2017-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国实用眼科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.11.004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
To investigate the preventive effect of low concentration of triamcinolone acetonide injected in anterior chamber on posterior capsular opacification.
Methods
A prospective clinical randomized controlled study of 120 patients with age-related cataract which diagnosed in Department of Ophthalmology of Zhongnan Hospital of Wuhan University were selected from March 2013 to March 2014. A total of 120 cases (120 eyes) were randomly divided into two groups and performed cataract phacoemulsification. The experimental group was injected triamcinolone acetonide (4 mg/100 ml, 0.2 ml) in anterior chamber after cataract phacoemulsification while the control group was injected sodium chloride (0.9%, 0.2 ml) in anterior chamber after operation. Postoperative follow-up 36 months, the incidence of postoperative posterior capsular opacification, early preoperative inflammatory response, intraocular pressure and corneal endothelial cells count in the two groups were observed.
Results
All 112 cases (112 eyes) were completed and included in the clinical analysis, including 54 cases (54 eyes) in experimental group and 58 cases (58 eyes) from control group. In the 3, 6, 12, 24 and 36 months after surgery, the incidence of postoperative posterior capsular opacification in the experimental group was lower than that in the control group (χ2=4.038, 7.377, 5.255, 4.809, 4.127, P 0.05).
Conclusions
Anterior chamber injection of low concentration of triamcinolone acetonide is an effective and safe way which can reduce and prevent the incidence of posterior capsular opacification and delay the onset of posterior capsular opacification after cataract phacoemulsification.
Key words:
Posterior capsular opacification; Triamcinolone acetonide; Intraocular pressure
期刊介绍:
China Practical Ophthalmology was founded in May 1983. It is supervised by the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association and China Medical University, and publicly distributed at home and abroad. It is a national-level excellent core academic journal of comprehensive ophthalmology and a series of journals of the Chinese Medical Association.
China Practical Ophthalmology aims to guide and improve the theoretical level and actual clinical diagnosis and treatment ability of frontline ophthalmologists in my country. It is characterized by close integration with clinical practice, and timely publishes academic articles and scientific research results with high practical value to clinicians, so that readers can understand and use them, improve the theoretical level and diagnosis and treatment ability of ophthalmologists, help and support their innovative development, and is deeply welcomed and loved by ophthalmologists and readers.