Exploration of the preventive effect of triamcinolone acetonide on posterior capsular opacification

Abstract

Objective To investigate the preventive effect of low concentration of triamcinolone acetonide injected in anterior chamber on posterior capsular opacification. Methods A prospective clinical randomized controlled study of 120 patients with age-related cataract which diagnosed in Department of Ophthalmology of Zhongnan Hospital of Wuhan University were selected from March 2013 to March 2014. A total of 120 cases (120 eyes) were randomly divided into two groups and performed cataract phacoemulsification. The experimental group was injected triamcinolone acetonide (4 mg/100 ml, 0.2 ml) in anterior chamber after cataract phacoemulsification while the control group was injected sodium chloride (0.9%, 0.2 ml) in anterior chamber after operation. Postoperative follow-up 36 months, the incidence of postoperative posterior capsular opacification, early preoperative inflammatory response, intraocular pressure and corneal endothelial cells count in the two groups were observed. Results All 112 cases (112 eyes) were completed and included in the clinical analysis, including 54 cases (54 eyes) in experimental group and 58 cases (58 eyes) from control group. In the 3, 6, 12, 24 and 36 months after surgery, the incidence of postoperative posterior capsular opacification in the experimental group was lower than that in the control group (χ2=4.038, 7.377, 5.255, 4.809, 4.127, P 0.05). Conclusions Anterior chamber injection of low concentration of triamcinolone acetonide is an effective and safe way which can reduce and prevent the incidence of posterior capsular opacification and delay the onset of posterior capsular opacification after cataract phacoemulsification. Key words: Posterior capsular opacification; Triamcinolone acetonide; Intraocular pressure