Formulate gastroretentive floating bioadhesive drug delivery system of nizatidine by direct compression technique

Abstract

Nizatidine is a gastroprotective drug with a short biological half-life and narrow absorption window. This study aimed at developing floating tablets of nizatidine using various HPMC viscosity grades, namely K4M, K15M, Carbopol 934P, Sodium alginate and sodium carboxy methyl cellulose. Directly compressed tablets revealed an excellent uniformity in hardness, thickness and weight and nizatidine was evenly distributed within the matrix floating tablets. Buoyancy study revealed the tablets remain buoyant for more than 12 h. Among all the formulations, F12 formulation containing 3:1 ratio of HPMC K15M and Carbopol 934P was found to be promising, which showed a floating lag time less than 5min and floating duration of more than 12 hours. It showed constant drug release up to 12 hours and good bio adhesion strength. All the designed formulations displayed zero order release kinetics and drug release follows non-Fickian diffusion mechanism.