Novel Resonance-Like Impedance Spectroscopy for Life Science Applications

Abstract

This paper presents a novel real-time resonance-like impedance spectroscopy method using ITO electrodes. These electrodes can exhibit N-Shape Nonlinear Negative Differential Resistance (NDR) under specific conditions. In these conditions, the impedance of the electrode becomes pure capacitive, resulting in a resonance-shape spectrum. The resonance frequency is related to electrochemical changes at the interface between electrode and sample. We validated this method using microfabricated ITO electrodes exposed to two chemical solutions, including DMEM culture medium and 0.9% NaCl Solution. Based on these results, the proposed method can offer great advantages of rapid impedance spectroscopy for high throughput screening of chemical and biological materials suitable for a variety of life sciences applications.