change of BDNF expression in traumatic brain injury after Kaempferia galanga L. administration

Abstract

BDNF has potent effects on neural synapses and its pathway affects cell survival and other biological processes. Kaempferia galanga L. has many active substances with antioxidant and anti-inflammatory effects. We analyzes BDNF in four different group of Wistar rats (Ratus novergicus) into Groups A (no trauma & extract), B (with trauma & no extract), C (with trauma and 600 mg/kgbw extract), and D (with trauma and 1200 mg/kgbw extract). Groups B, C, and D are further divided into those who had their BDNF measured on 24- (B24, C24, and D24) and 48-hours. BDNF expression were found to be statistically significant between Group A with both B24 (p = 0,009) and D24 (p = 0,009) on the 24-hour post-trauma decapitation analysis. On the 48 hours after trauma and extract administration, Group B48 (p = 0,002), C48 (p = <0,001), and D48 (p <0,001) were found to be significantly different with Group A. The administration of Kaempferia galanga L. extract can be considered as an option in increasing brain BDNF levels which are neuroprotective. Larger and specific studies are needed to determine the appropriate dose and duration.