A Review on Platensimycin: A Selective FabF Inhibitor

Manik Das, Partha Sakha Ghosh, K. Manna
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引用次数: 11

Abstract

Emerging resistance to existing antibiotics is an inevitable matter of concern in the treatment of bacterial infection. Naturally occurring unique class of natural antibiotic, platensimycin, a secondary metabolite from Streptomyces platensis, is an excellent breakthrough in recent antibiotic research with unique structural pattern and significant antibacterial activity. β-Ketoacyl-(acyl-carrier-protein (ACP)) synthase (FabF) whose Gram-positive bacteria need to biosynthesize cell membranes is the target of inhibition of platensimycin. So, isolation, retrosynthetic analysis, synthesis of platensimycin, and analogues of platensimycin synthesized till today are the objectives of this review which may be helpful to further investigate and to reveal untouched area on this molecule and to obtain a potential antibacterial lead with enhanced significant antibacterial activity.
选择性FabF抑制剂铂霉素的研究进展
对现有抗生素的新耐药性是细菌感染治疗中不可避免的问题。platensimycin是天然存在的一类独特的天然抗生素,platensimycin是platptomyces platensis的次级代谢产物,具有独特的结构模式和显著的抗菌活性,是近年来抗生素研究的一个优秀突破。革兰氏阳性菌生物合成细胞膜所需的β-酮酰基-(酰基载体蛋白(ACP))合成酶(FabF)是铂霉素抑制的靶点。因此,本文对铂霉素分子的分离、反合成分析、合成及迄今为止合成的铂霉素类似物进行综述,以期进一步研究和揭示其未被开发的领域,获得具有显著抗菌活性的潜在抗菌先导物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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期刊介绍: International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.
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