The effect of coronavirus on the body’s immune system (the literature review)

Aruzhan Berikkyzy, N. Ablaikhanova, G. Tusupbekova, L. Kozhamzharova
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Abstract

This article presents the scientific review on the functional state of the living organism in coronavirus disease (COVID-19). Increased cytokine release in response to viral infection, known as cytokine release syndrome or cytokine storm, becomes a mechanism leading to acute respiratory distress syndrome (ARDS) and multiple organ failure (MOF) in COVID-19, thus supporting the hypothesis that appropriately selected antiinflammatory therapeutic strategies can improve clinical outcomes and patient progress. Cytokines are low molecular weight proteins secreted by the body’s immune cells, in normal amounts have a protective effect on the body related to the delimitation of damaged tissue during inflammation. Currently, there are more than 30 types, divided into several independent groups according to their structural features and biological action. As there are no uniform diagnostic criteria for a cytokine storm, the main focus of laboratory diagnosis is on elevations of interleukin-1β (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP) and ferritin, procalcitonin.
冠状病毒对人体免疫系统的影响(文献综述)
本文综述了新型冠状病毒病(COVID-19)中生物功能状态的科学进展。病毒感染后细胞因子释放增加,被称为细胞因子释放综合征或细胞因子风暴,成为导致COVID-19患者急性呼吸窘迫综合征(ARDS)和多器官衰竭(MOF)的机制,从而支持适当选择抗炎治疗策略可以改善临床结果和患者进展的假设。细胞因子是由机体免疫细胞分泌的低分子量蛋白质,在正常量下对机体炎症期间受损组织的划界有保护作用。目前有30多种,根据它们的结构特征和生物作用分为几个独立的类群。由于细胞因子风暴没有统一的诊断标准,实验室诊断的主要重点是白细胞介素-1β (IL-1β)、白细胞介素-6 (IL-6)、c反应蛋白(CRP)和铁蛋白、降钙素原的升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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