In vitro antioxidant activity and in vivo alpha glucosidase activity of endophytic actinomycetes isolated from Catharanthus roseus (l.) G. Don

Abstract

Aim

Antioxidant compounds in food play an important role as a health protecting factor. Scientific evidence suggests that antioxidants reduce the risk for chronic diseases including cancer and heart disease. The present study was to evaluate the free radical scavenging activity and alpha glucosidase activity of Ethyl acetate extracts of endophytic actinomycetes (EEA) isolated from the roots of Catharanthus roseus (l.) G. Don.

Method

The EEA was screened for its capability in lowering blood sugar level and radical scavenging activity against Hydroxyl (HO^-), Hydrogen peroxide (H₂O₂), Nitric oxide (NO) and scavenging of stable radical 2,2-diphenyl-1-picrylhydrazyl or DPPH and using standard procedures.

Result

Significant free radical scavenging activity and marked alpha glucosidase activity were exhibited by EEA isolated from the roots of Catharanthus roseus (l.) G. Don.

Conclusion

The extract used in the study possesses significant antioxidant activity as well as an alpha glucosidase inhibition and have the potential for application in pharmaceuticals.